Biomaterial-based platforms for tumour tissue engineering
Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …
based on molecularly designed biomaterials aim to harness the dimensionality and …
Bioengineering 3D environments for cancer models
M Alemany-Ribes, CE Semino - Advanced drug delivery reviews, 2014 - Elsevier
Tumor development is a dynamic process where cancer cells differentiate, proliferate and
migrate interacting among each other and with the surrounding matrix in a three …
migrate interacting among each other and with the surrounding matrix in a three …
Heralding a new paradigm in 3D tumor modeling
Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …
from the traditional two-dimensional culture system to three-dimensional (3D) culture …
Biomaterials offer cancer research the third dimension
DW Hutmacher - Nature materials, 2010 - nature.com
Biomaterials offer cancer research the third dimension | Nature Materials Skip to main content
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Three-dimensional in vitro tumor models for cancer research and drug evaluation
Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …
Cancer tissue engineering-new perspectives in understanding the biology of solid tumours-a critical review
Understanding cancer biology is a major challenge of this century. The recent insight about
carcinogenesis mechanisms, including the role exerted by the tumour microenvironment …
carcinogenesis mechanisms, including the role exerted by the tumour microenvironment …
[HTML][HTML] Engineering cancer microenvironments for in vitro 3-D tumor models
The natural microenvironment of tumors is composed of extracellular matrix (ECM), blood
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …
Toward the broad adoption of 3D tumor models in the cancer drug pipeline
MC Cox, LM Reese, LR Bickford… - … Biomaterials Science & …, 2015 - ACS Publications
Despite a cost of approximately $1 billion to develop a new cancer drug, about 90% of drugs
that enter clinical trials fail. A tremendous opportunity exists to streamline the drug selection …
that enter clinical trials fail. A tremendous opportunity exists to streamline the drug selection …
A versatile 3D tissue matrix scaffold system for tumor modeling and drug screening
Most of the anticancer drug candidates entering preclinical trials fail to be approved for
clinical applications. The following are among the main causes of these failures: studying …
clinical applications. The following are among the main causes of these failures: studying …
Modeling tumor microenvironments using custom-designed biomaterial scaffolds
Z Liu, G Vunjak-Novakovic - Current opinion in chemical engineering, 2016 - Elsevier
HighlightsThe tumor microenvironment regulates tumor initiation, progression, and
metastasis.We summarize the use of biomaterials in tumor modeling in vitro.Engineered …
metastasis.We summarize the use of biomaterials in tumor modeling in vitro.Engineered …