Biomaterial-based platforms for tumour tissue engineering

R Curvello, V Kast, P Ordóñez-Morán, A Mata… - Nature Reviews …, 2023 - nature.com
Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …

Bioengineering 3D environments for cancer models

M Alemany-Ribes, CE Semino - Advanced drug delivery reviews, 2014 - Elsevier
Tumor development is a dynamic process where cancer cells differentiate, proliferate and
migrate interacting among each other and with the surrounding matrix in a three …

Heralding a new paradigm in 3D tumor modeling

ELS Fong, DA Harrington, MC Farach-Carson, H Yu - Biomaterials, 2016 - Elsevier
Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …

Biomaterials offer cancer research the third dimension

DW Hutmacher - Nature materials, 2010 - nature.com
Biomaterials offer cancer research the third dimension | Nature Materials Skip to main content
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Three-dimensional in vitro tumor models for cancer research and drug evaluation

X Xu, MC Farach-Carson, X Jia - Biotechnology advances, 2014 - Elsevier
Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …

Cancer tissue engineering-new perspectives in understanding the biology of solid tumours-a critical review

C Ricci, L Moroni, S Danti - OA Tissue Engineering, 2013 - research.utwente.nl
Understanding cancer biology is a major challenge of this century. The recent insight about
carcinogenesis mechanisms, including the role exerted by the tumour microenvironment …

[HTML][HTML] Engineering cancer microenvironments for in vitro 3-D tumor models

W Asghar, R El Assal, H Shafiee, S Pitteri… - Materials today, 2015 - Elsevier
The natural microenvironment of tumors is composed of extracellular matrix (ECM), blood
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …

Toward the broad adoption of 3D tumor models in the cancer drug pipeline

MC Cox, LM Reese, LR Bickford… - … Biomaterials Science & …, 2015 - ACS Publications
Despite a cost of approximately $1 billion to develop a new cancer drug, about 90% of drugs
that enter clinical trials fail. A tremendous opportunity exists to streamline the drug selection …

A versatile 3D tissue matrix scaffold system for tumor modeling and drug screening

G Rijal, W Li - Science advances, 2017 - science.org
Most of the anticancer drug candidates entering preclinical trials fail to be approved for
clinical applications. The following are among the main causes of these failures: studying …

Modeling tumor microenvironments using custom-designed biomaterial scaffolds

Z Liu, G Vunjak-Novakovic - Current opinion in chemical engineering, 2016 - Elsevier
Highlights⿢The tumor microenvironment regulates tumor initiation, progression, and
metastasis.⿢We summarize the use of biomaterials in tumor modeling in vitro.⿢Engineered …