Long noncoding RNAs (lncRNAs) and promoter-or enhancer-associated unstable
transcripts locate preferentially to chromatin, where some regulate chromatin structure …

Long noncoding RNAs (lncRNAs) are emerging as key parts of multiple cellular pathways,
but their modes of action and how these are dictated by sequence remain unclear. lncRNAs …

In eukaryotes, U1 small nuclear ribonucleoprotein (snRNP) forms spliceosomes in equal
stoichiometry with U2, U4, U5 and U6 snRNPs; however, its abundance in human far …

Mammalian genomes are pervasively transcribed, to produce thousands of long non-coding
RNAs (lncRNAs),. A few of these lncRNAs have been shown to recruit regulatory complexes …

There is growing recognition that mammalian cells produce many thousands of large
intergenic transcripts,,,. However, the functional significance of these transcripts has been …

In contrast to cytoplasmic localization of spliced mRNAs, many spliced lncRNAs are
localized in the nucleus. To investigate the mechanism, we used lncRNA MEG3 as a …

Beyond coding for proteins, RNA molecules have well-established functions in the
posttranscriptional regulation of gene expression. Less clear are the upstream roles of RNA …

Recent advances in genomic research have revealed the existence of a large number of
transcripts devoid of protein-coding potential in multiple organisms,,,,,,,. Although the …

Long non-coding RNAs (lncRNAs) are largely heterogeneous and functionally
uncharacterized. Here, using FANTOM5 cap analysis of gene expression (CAGE) data, we …

A large fraction of the mammalian genome is transcribed into long noncoding RNAs. The
RNAs remain largely uncharacterized as the field awaits new technologies to aid functional …