Tissue engineering approaches combine a bioscaffold with stem cells to provide biological
substitutes that can repair bone defects and eventually improve tissue functions. The …

The regeneration of artificial bone substitutes is a potential strategy for repairing bone
defects. However, the development of substitutes with appropriate osteoinductivity and …

Biomimetic calcium phosphate mineralized graphene oxide/chitosan (GO/CS) scaffolds with
hierarchical structures were developed. First, GO/CS scaffolds with large micropores (∼ 300 …

Facilitated endogenous tissue engineering is emerging as a convenient and easy strategy
for bone repair. However, the substitution with satisfactory bioactivity and osteoinductivity …

Graphene oxide and chitosan are promising materials for tissue regeneration. The present
study explores a novel biomimetic mineralization route employing a graphene oxide (GO) …

Hydroxyapatite (HA), the traditional bone tissue replacement material was widely used in the
clinical treatment of bone defects because of its excellent biocompatibility. However, the …

In bone tissue engineering, it is imperative to design multifunctional biomaterials that can
induce and assemble bonelike apatite that is close to natural bone. In this study, graphene …

Background Nanocomposites produced by reinforcement of polysaccharide matrix with
nanoparticles are widely used in engineering of biomaterials. However, clinical applications …

Two-dimensional materials provide a secluded space for bone formation and preserve the
growth of surrounding tissues, thus playing a crucial role in guided bone regeneration …

The strontium-substituted hydroxyapatite (SrHA) is a commonly used material in bone
regeneration for its good osteoconductivity and high alkaline phosphatase (ALP) activity …