[HTML][HTML] Protective mechanism of humanin against oxidative stress in aging-related cardiovascular diseases

H Cai, Y Liu, H Men, Y Zheng - Frontiers in Endocrinology, 2021 - frontiersin.org
Physiological reactive oxygen species (ROS) are important regulators of intercellular signal
transduction. Oxidative and antioxidation systems maintain a dynamic balance under …

[HTML][HTML] Humanin and its pathophysiological roles in aging: A systematic review

D Coradduzza, A Congiargiu, Z Chen, S Cruciani… - Biology, 2023 - mdpi.com
Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …

Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice

Q Qin, H Mehta, K Yen, G Navarrete… - American Journal …, 2018 - journals.physiology.org
Cardiac fibrosis is a biological process that increases with age and contributes to myocardial
dysfunction. Humanin (HN) is an endogenous mitochondria-derived peptide that has …

[HTML][HTML] Humanin and age-related diseases: a new link?

Z Gong, E Tas, R Muzumdar - Frontiers in endocrinology, 2014 - frontiersin.org
Humanin (HN) is 24-amino acid mitochondria-associated peptide. Since its initial discovery
over a decade ago, a role for HN has been reported in many biological processes such as …

Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity

S Thummasorn, K Shinlapawittayatorn… - Mitochondrion, 2018 - Elsevier
Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress
and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can …

[HTML][HTML] The emerging role of the mitochondrial-derived peptide humanin in stress resistance

K Yen, C Lee, H Mehta, P Cohen - Journal of molecular …, 2013 - ncbi.nlm.nih.gov
The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially
new category of biologically active peptide. As more research unravels the endogenous role …

Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice

X Zhang, VH Urbieta-Caceres, A Eirin, CC Bell… - Life sciences, 2012 - Elsevier
AIMS: Humanin (HN) is an endogenous mitochondrial-derived cytoprotective peptide that
has shown protective effects against atherosclerosis and is expressed in human vessels …

Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress

AR Bachar, L Scheffer, AS Schroeder… - Cardiovascular …, 2010 - academic.oup.com
Aims Humanin (HN) is a 24-amino acid peptide that has been shown to have an anti-
apoptotic function against neuronal cell death caused by Alzheimer's disease. Increased …

Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose‐related oxidative stress

A Voigt, HF Jelinek - Physiological reports, 2016 - Wiley Online Library
Abstract Mitochondrial RNR‐2 (mt‐RNR 2, humanin) has been shown to play a role in
protecting several types of cells and tissues from the effects of oxidative stress. Humanin …

A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts

LE Klein, L Cui, Z Gong, K Su, R Muzumdar - Biochemical and biophysical …, 2013 - Elsevier
A potent analog (HNG) of the endogenous peptide humanin protects against myocardial
ischemia–reperfusion (MI–R) injury in vivo, decreasing infarct size and improving cardiac …