[HTML][HTML] Protective mechanism of humanin against oxidative stress in aging-related cardiovascular diseases
H Cai, Y Liu, H Men, Y Zheng - Frontiers in Endocrinology, 2021 - frontiersin.org
Physiological reactive oxygen species (ROS) are important regulators of intercellular signal
transduction. Oxidative and antioxidation systems maintain a dynamic balance under …
transduction. Oxidative and antioxidation systems maintain a dynamic balance under …
[HTML][HTML] Humanin and its pathophysiological roles in aging: A systematic review
D Coradduzza, A Congiargiu, Z Chen, S Cruciani… - Biology, 2023 - mdpi.com
Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …
number of potential therapeutic applications for various age-related diseases. It plays an …
Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice
Cardiac fibrosis is a biological process that increases with age and contributes to myocardial
dysfunction. Humanin (HN) is an endogenous mitochondria-derived peptide that has …
dysfunction. Humanin (HN) is an endogenous mitochondria-derived peptide that has …
[HTML][HTML] Humanin and age-related diseases: a new link?
Z Gong, E Tas, R Muzumdar - Frontiers in endocrinology, 2014 - frontiersin.org
Humanin (HN) is 24-amino acid mitochondria-associated peptide. Since its initial discovery
over a decade ago, a role for HN has been reported in many biological processes such as …
over a decade ago, a role for HN has been reported in many biological processes such as …
Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
S Thummasorn, K Shinlapawittayatorn… - Mitochondrion, 2018 - Elsevier
Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress
and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can …
and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can …
[HTML][HTML] The emerging role of the mitochondrial-derived peptide humanin in stress resistance
The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially
new category of biologically active peptide. As more research unravels the endogenous role …
new category of biologically active peptide. As more research unravels the endogenous role …
Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice
AIMS: Humanin (HN) is an endogenous mitochondrial-derived cytoprotective peptide that
has shown protective effects against atherosclerosis and is expressed in human vessels …
has shown protective effects against atherosclerosis and is expressed in human vessels …
Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress
AR Bachar, L Scheffer, AS Schroeder… - Cardiovascular …, 2010 - academic.oup.com
Aims Humanin (HN) is a 24-amino acid peptide that has been shown to have an anti-
apoptotic function against neuronal cell death caused by Alzheimer's disease. Increased …
apoptotic function against neuronal cell death caused by Alzheimer's disease. Increased …
Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose‐related oxidative stress
A Voigt, HF Jelinek - Physiological reports, 2016 - Wiley Online Library
Abstract Mitochondrial RNR‐2 (mt‐RNR 2, humanin) has been shown to play a role in
protecting several types of cells and tissues from the effects of oxidative stress. Humanin …
protecting several types of cells and tissues from the effects of oxidative stress. Humanin …
A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts
LE Klein, L Cui, Z Gong, K Su, R Muzumdar - Biochemical and biophysical …, 2013 - Elsevier
A potent analog (HNG) of the endogenous peptide humanin protects against myocardial
ischemia–reperfusion (MI–R) injury in vivo, decreasing infarct size and improving cardiac …
ischemia–reperfusion (MI–R) injury in vivo, decreasing infarct size and improving cardiac …
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