Renal cell carcinoma (RCC) constitutes more than 90% of primary kidney tumors with the
development of metastatic disease in the lung, bone, liver, and brain. Clear-cell RCC …

Simple Summary Inflammation is an important hallmark of advanced renal cell carcinoma
and plays a pivotal role in tumor progression, metastasis, and anti-cancer resistance …

Substantial research attention has been directed at exploring the mechanisms and treatment
of renal cell carcinoma (RCC). Indeed, the association between inflammation and tumor …

Simple Summary Over the last decade there has been a significant increase in the number
of therapies that activate the host's immune system to target and eliminate renal cell …

Renal cell carcinoma (RCC) is a malignant tumor associated with various tumor
microenvironments (TMEs). The immune system is activated by the development of cancer …

Up to one third of patients diagnosed with renal cell carcinoma (RCC) have metastases at
initial presentation, and nearly 40% of patients with localized disease will develop …

Angiogenesis and immunosuppression work hand‐in‐hand in the renal cell carcinoma
(RCC) microenvironment. Tumor growth is associated with impaired antitumor immune …

Purpose: Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation
of the von Hippel–Lindau tumor suppressor, resulting in activation of HIF-1α and HIF-2α. The …

The tumor immune microenvironment plays a critical role in cancer progression and
response to immunotherapy in clear cell renal cell carcinoma (ccRCC), yet the composition …

The clear evidence that tumor-infiltrating lymphocytes with anti-tumor activity exist in situ
raises the question why renal cell carcinomas (RCCs) progress in vivo. A complex array of …