Background The main objective of this study was to analyze the effects of KRAS/TP53
mutation status and tumor sideness on the immune microenvironment of colorectal cancer …

Introduction Colorectal cancer (CRC) is a highly heterogeneous cancer. The molecular and
cellular characteristics differ between the colon and rectal cancer type due to the differences …

Background KRAS gene is the most common type of mutation reported in colorectal cancer
(CRC). KRAS mutation-mediated regulation of immunophenotype and immune pathways in …

Profiling heterologous cell types within tumors is essential to decipher tumor
microenvironment that shapes tumor progress and determines the outcome of therapeutic …

Single cell RNA sequencing (scRNA-seq) is a novel high-throughput technique that enables
the investigation of a single cell's entire transcriptome. It elucidates intricate cellular …

Simple Summary The poor prognosis outcome of patients with KRAS mutations (KRAS mut)
was correlated with an immunosuppressive tumor microenvironment (TME). At the gene …

Introduction Colorectal cancer (CRC) ranks second for mortality and third for morbidity
among the most commonly diagnosed cancers worldwide. We aimed to investigate the …

The immune microenvironment has profound impacts on the initiation and progression of
colorectal cancer (CRC). Therefore, the goal of this article is to identify two robust immune …

Background Biomarkers based on immune context may guide prognosis prediction. T-cell
inactivation, exclusion, or dysfunction could cause unfavorable tumor microenvironments …

Colorectal cancer (CRC) is a malignancy that is both highly lethal and heterogeneous.
Although the correlation between intra-tumoral genetic and functional heterogeneity and …