Regulation of leaderless mRNA translation in bacteria
LE Leiva, A Katz - Microorganisms, 2022 - mdpi.com
In bacteria, the translation of genetic information can begin through at least three different
mechanisms: canonical or Shine-Dalgarno-led initiation, readthrough or 70S scanning …
mechanisms: canonical or Shine-Dalgarno-led initiation, readthrough or 70S scanning …
An AUG initiation codon, not codon–anticodon complementarity, is required for the translation of unleadered mRNA in Escherichia coli
WJ Van Etten, GR Janssen - Molecular microbiology, 1998 - Wiley Online Library
We determined the in vivo translational efficiency of 'unleadered'lacZ compared with a
conventionally leadered lacZ with and without a Shine–Dalgarno (SD) sequence in …
conventionally leadered lacZ with and without a Shine–Dalgarno (SD) sequence in …
Leaderless mRNAs in bacteria: surprises in ribosomal recruitment and translational control
It is commonly believed that the translational efficiency of prokaryotic mRNAs is intrinsically
determined by both primary and secondary structures of their translational initiation regions …
determined by both primary and secondary structures of their translational initiation regions …
Translational initiation in E. coli occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing
Shine-Dalgarno (SD) motifs are thought to play an important role in translational initiation in
bacteria. Paradoxically, ribosome profiling studies in E. coli show no correlation between the …
bacteria. Paradoxically, ribosome profiling studies in E. coli show no correlation between the …
Leaderless mRNAs in the spotlight: ancient but not outdated!
In bacteria and archaea, translation initiates with a 30S ribosomal subunit interacting with an
initiator tRNA at the ribosome binding site on a canonical mRNA to form a stable translation …
initiator tRNA at the ribosome binding site on a canonical mRNA to form a stable translation …
Translation initiation with 70S ribosomes: an alternative pathway for leaderless mRNAs
It is generally accepted that translation in bacteria is initiated by 30S ribosomal subunits. In
contrast, several lines of rather indirect in vitro evidence suggest that 70S monosomes are …
contrast, several lines of rather indirect in vitro evidence suggest that 70S monosomes are …
Evidence against an interaction between the mRNA downstream box and 16S rRNA in translation initiation
I Moll, M Huber, S Grill, P Sairafi, F Mueller… - Journal of …, 2001 - Am Soc Microbiol
Based on the complementarity of the initial coding region (downstream box [db]) of several
bacterial and phage mRNAs to bases 1469 to 1483 in helix 44 of 16S rRNA (anti …
bacterial and phage mRNAs to bases 1469 to 1483 in helix 44 of 16S rRNA (anti …
Translation initiation factor 3 antagonizes authentic start codon selection on leaderless mRNAs
K Tedin, I Moll, S Grill, A Resch… - Molecular …, 1999 - Wiley Online Library
In this study, we have examined the influence of initiation factors on translation initiation of
leaderless mRNAs whose 5′‐terminal residues are the A of the AUG initiating codon. A 1: 1 …
leaderless mRNAs whose 5′‐terminal residues are the A of the AUG initiating codon. A 1: 1 …
Evidence for the translation initiation of leaderless mRNAs by the intact 70 S ribosome without its dissociation into subunits in eubacteria
In eubacteria, the dissociation of the 70 S ribosome into the 30 S and 50 S subunits is the
essential first step for the translation initiation of canonical mRNAs that possess 5′-leader …
essential first step for the translation initiation of canonical mRNAs that possess 5′-leader …
Local absence of secondary structure permits translation of mRNAs that lack ribosome-binding sites
LB Scharff, L Childs, D Walther, R Bock - PLoS genetics, 2011 - journals.plos.org
The initiation of translation is a fundamental and highly regulated process in gene
expression. Translation initiation in prokaryotic systems usually requires interaction between …
expression. Translation initiation in prokaryotic systems usually requires interaction between …