Analysis of miRNA regulation suggests an explanation for 'unexpected'increase in target protein levels

SA Gokhale, CJ Gadgil - Molecular BioSystems, 2012 - pubs.rsc.org
MicroRNA (miRNA) has been mostly associated with decrease in target protein expression
levels. Recently,'unexpected'observations of increase in target protein expression attributed …

Quantifying negative feedback regulation by micro-RNAs

S Wang, S Raghavachari - Physical biology, 2011 - iopscience.iop.org
Micro-RNAs (miRNAs) play a crucial role in post-transcriptional gene regulation by pairing
with target mRNAs to repress protein production. It has been shown that over one-third of …

[HTML][HTML] Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells

A Baccarini, H Chauhan, TJ Gardner, AD Jayaprakash… - Current biology, 2011 - cell.com
Considerable details about microRNA (miRNA) biogenesis and regulation have been
uncovered, but little is known about the fate of the miRNA subsequent to target regulation …

Mathematical modeling of combinatorial regulation suggests that apparent positive regulation of targets by miRNA could be an artifact resulting from competition for …

D Nyayanit, CJ Gadgil - Rna, 2015 - rnajournal.cshlp.org
MicroRNAs bind to and regulate the abundance and activity of target messenger RNA
through sequestration, enhanced degradation, and suppression of translation. Although …

Slowly produced microRNAs control protein levels

ZL Whichard, AE Motter, PJ Stein, SJ Corey - Journal of Biological …, 2011 - ASBMB
Proteins are the primary agents of function in biological systems, and their levels are critical
control elements, reflecting the interplay between transcription, translation, and protein …

Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation

J Vohradsky, J Panek, T Vomastek - Nucleic acids research, 2010 - academic.oup.com
Post-transcriptional control of mRNA by micro-RNAs (miRNAs) represents an important
mechanism of gene regulation. miRNAs act by binding to the 3′ untranslated region (3 …

Target-specific and global effectors in gene regulation by MicroRNA

E Levine, EB Jacob, H Levine - Biophysical journal, 2007 - cell.com
MicroRNAs are responsible for post-transcriptional gene silencing as part of critical cellular
pathways and intercellular coordination, for example during embryonic development. Yet …

Conditions of appreciable influence of microRNA on a large number of target mRNAs

VP Zhdanov - Molecular bioSystems, 2009 - pubs.rsc.org
In eukaryotic cells, messenger RNAs (mRNAs) can be regulated by microRNAs (miRNAs)
via association and subsequent degradation. Each miRNA is now believed to potentially …

Computational modeling of post-transcriptional gene regulation by microRNAs

R Khanin, V Vinciotti - Journal of Computational Biology, 2008 - liebertpub.com
MicroRNAs (miRNAs) have recently emerged as a new complex layer of gene regulation.
MiRNAs act post-transcriptionally, influencing the stability, compartmentalization, and …

Kinetic signatures of microRNA modes of action

N Morozova, A Zinovyev, N Nonne, LL Pritchard… - Rna, 2012 - rnajournal.cshlp.org
MicroRNAs (miRNAs) are key regulators of all important biological processes, including
development, differentiation, and cancer. Although remarkable progress has been made in …