Analysis of miRNA regulation suggests an explanation for 'unexpected'increase in target protein levels
SA Gokhale, CJ Gadgil - Molecular BioSystems, 2012 - pubs.rsc.org
MicroRNA (miRNA) has been mostly associated with decrease in target protein expression
levels. Recently,'unexpected'observations of increase in target protein expression attributed …
levels. Recently,'unexpected'observations of increase in target protein expression attributed …
Quantifying negative feedback regulation by micro-RNAs
S Wang, S Raghavachari - Physical biology, 2011 - iopscience.iop.org
Micro-RNAs (miRNAs) play a crucial role in post-transcriptional gene regulation by pairing
with target mRNAs to repress protein production. It has been shown that over one-third of …
with target mRNAs to repress protein production. It has been shown that over one-third of …
[HTML][HTML] Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells
A Baccarini, H Chauhan, TJ Gardner, AD Jayaprakash… - Current biology, 2011 - cell.com
Considerable details about microRNA (miRNA) biogenesis and regulation have been
uncovered, but little is known about the fate of the miRNA subsequent to target regulation …
uncovered, but little is known about the fate of the miRNA subsequent to target regulation …
Mathematical modeling of combinatorial regulation suggests that apparent positive regulation of targets by miRNA could be an artifact resulting from competition for …
D Nyayanit, CJ Gadgil - Rna, 2015 - rnajournal.cshlp.org
MicroRNAs bind to and regulate the abundance and activity of target messenger RNA
through sequestration, enhanced degradation, and suppression of translation. Although …
through sequestration, enhanced degradation, and suppression of translation. Although …
Slowly produced microRNAs control protein levels
Proteins are the primary agents of function in biological systems, and their levels are critical
control elements, reflecting the interplay between transcription, translation, and protein …
control elements, reflecting the interplay between transcription, translation, and protein …
Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation
J Vohradsky, J Panek, T Vomastek - Nucleic acids research, 2010 - academic.oup.com
Post-transcriptional control of mRNA by micro-RNAs (miRNAs) represents an important
mechanism of gene regulation. miRNAs act by binding to the 3′ untranslated region (3 …
mechanism of gene regulation. miRNAs act by binding to the 3′ untranslated region (3 …
Target-specific and global effectors in gene regulation by MicroRNA
MicroRNAs are responsible for post-transcriptional gene silencing as part of critical cellular
pathways and intercellular coordination, for example during embryonic development. Yet …
pathways and intercellular coordination, for example during embryonic development. Yet …
Conditions of appreciable influence of microRNA on a large number of target mRNAs
VP Zhdanov - Molecular bioSystems, 2009 - pubs.rsc.org
In eukaryotic cells, messenger RNAs (mRNAs) can be regulated by microRNAs (miRNAs)
via association and subsequent degradation. Each miRNA is now believed to potentially …
via association and subsequent degradation. Each miRNA is now believed to potentially …
Computational modeling of post-transcriptional gene regulation by microRNAs
R Khanin, V Vinciotti - Journal of Computational Biology, 2008 - liebertpub.com
MicroRNAs (miRNAs) have recently emerged as a new complex layer of gene regulation.
MiRNAs act post-transcriptionally, influencing the stability, compartmentalization, and …
MiRNAs act post-transcriptionally, influencing the stability, compartmentalization, and …
Kinetic signatures of microRNA modes of action
N Morozova, A Zinovyev, N Nonne, LL Pritchard… - Rna, 2012 - rnajournal.cshlp.org
MicroRNAs (miRNAs) are key regulators of all important biological processes, including
development, differentiation, and cancer. Although remarkable progress has been made in …
development, differentiation, and cancer. Although remarkable progress has been made in …