Rheumatoid arthritis (RA) is a debilitating autoimmune disorder with an inflammatory
condition targeting the joints that affects millions of patients worldwide. Several unmet needs …

Rheumatoid arthritis is a prevalent and debilitating chronic disease worldwide. Targeting
Janus kinase 3 (JAK3) has emerged as a crucial molecular strategy to treat this condition. In …

Rheumatoid arthritis is a chronic autoimmune illness characterized by joint dysfunction. New
drugs are available, among them Janus Kinase enzyme inhibitor drugs, whose significant …

Multiple cytokines play a pivotal role in the pathogenesis of Rheumatoid Arthritis by inducing
intracellular signaling and it is known that the members of the Janus kinase (JAK) family are …

Rheumatoid arthritis (RA) is a chronic immune-related condition, primarily of joints, and is
highly disabling and painful. The inhibition of Janus kinase (JAK)-related cytokine signaling …

Objective: This study aimed to discover a novel active compound capable of effectively
inhibiting JAK3/STAT1 and CYP3A4 using molecular modelling techniques, with the goal of …

Rheumatoid arthritis is a common chronic disabling inflammatory disease that is
characterized by inflammation of the synovial membrane and leads to discomfort. In the …

Janus kinases (JAKs) play a critical role in modulating the function and expression of
inflammatory cytokines related to rheumatoid arthritis (RA). Herein, we report the design …

Janus kinase inhibitors represent a promising opportunity for the pharmaceutical
intervention of various inflammatory and oncological indications. Subtype selective inhibition …

Nyctanthes arbor tristis L (NAT) is one of the herbal plants whose parts are commonly used
to treat diverse ailment including RA. Although the etiology of the autoimmune disorder RA …