In several tumors the PI3K/AKT/mTOR pathway is frequently disrupted, an event that results
in uncontrolled cell proliferation and tumor growth. Through the years, several compounds …

The serine/threonine kinase, mTOR (mammalian Target of Rapamycin) has become a focus
for cancer drug development. Rapamycins are highly specific inhibitors of mTOR and …

Deregulation of the phosphatidylinositide 3-kinase (PI3K) and mammalian target of
rapamycin (mTOR) signaling pathway occurs frequently in a wide range of human cancers …

Abstract The phosphoinositide 3-kinase-AKT-mammalian target of rapamycin (PI3K-AKT-
mTOR) pathway is a frequently hyperactivated pathway in cancer and is important for tumor …

Delineating the contributions of specific cell signalling cascades to the development and
maintenance of tumours has greatly informed our understanding of tumorigenesis and has …

Background Most targeted anticancer therapies, as well as cytotoxic and radiation therapies,
are encumbered by the development of secondary resistance by cancer cells. Resistance is …

The mammalian target of rapamycin (mTOR) pathway plays a central role in regulating
protein synthesis, ribosomal protein translation, and cap-dependent translation …

Among many cancer cells signaling pathways, PI3K-AKT-mTOR plays a major role in
growth, proliferation and cellular survival. This is a complex pathway activated either by an …

The development of drug-resistance by neoplastic cells is recognized as a major cause of
targeted therapy failure and disease progression. The mechanistic (previously mammalian) …

Highlights•Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase
involved in metabolism regulation.•Increasing evidence reports that mTOR dysregulation is …