Every year over two hundred million people are infected with the malaria parasite. Renewed
efforts to eliminate malaria has highlighted the potential to interrupt transmission from …

Renewed efforts to eliminate malaria have highlighted the potential to interrupt human-to-
mosquito transmission—a process mediated by gametocyte kinetics in human hosts. Here …

Introduction In areas of seasonal malaria, resuming transmission every wet season relies on
persistent asexual parasites during dry season that maintain the ability to produce …

Background The burden of falciparum malaria remains unacceptably high in much of sub-
Saharan Africa and massive efforts are underway to eliminate the parasite. While symptoms …

Malaria, a vector borne disease caused by Plasmodium spp., remains a major global cause
of morbidity and mortality. Optimization of the disease control strategies requires a thorough …

Understanding the importance of gametocyte density on human-to-mosquito transmission is
of immediate relevance to malaria control. Previous work (Churcher et al., 2013) indicated a …

Transmission reduction is a key component of global efforts to control and eliminate malaria;
yet, it is unclear how the density of transmission stages (gametocytes) influences infection …

Efforts to control malaria worldwide have led to significant progress in treating and
preventing malaria, yet over 228 million infections were reported in 2018. Each infection is a …

Many models of within-host malaria infection dynamics have been formulated since the
pioneering work of Anderson et al. in 1989. Biologically, the goal of these models is to …

Background: Malaria elimination strategies require a thorough understanding of parasite
transmission from human to mosquito. A clinical model to induce gametocytes to understand …