Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of
synaptic and extrasynaptic GABAA receptors. Herein, we report new SAR insights in a series …

Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of
synaptic and extrasynaptic GABA A receptors. Herein, we report new SAR insights in a …

Neuroactive steroids (NASs) have been shown to impact central nervous system (CNS)
function through positive allosteric modulation of the GABAA receptor (GABAA-R). Herein …

The term “neuroactive steroid”(NAS) refers to steroids which, independent of their origin, are
capable of modifying neural activities. These steroids positively or negatively modulate the …

Neurosteroids positively and negatively modulate γ-aminobutyric acid (GABA) A receptors
and glutamate receptors, which underlie most fast inhibition and excitation in the central …

Wu, Pharmaceuticals (2009) 2: 77-81. Jiang. X., et al., Neurosteroid analogues. 9.
Conformationally constrained pregnanes: structure-activity studies of 13.24-cyclo 18, 21 …

Neuroactive steroids are a novel class of positive allosteric modulators of the GABA A
receptor. Although neuroactive steroids are endogenous neuronal modulators, synthetic …

The neuroactive steroid (NAS) tetrahydrodeoxycorticosterone (THDOC) increases protein
kinase C (PKC) mediated phosphorylation of extrasynaptic GABA A receptor (GABA AR) …

Neurosteroids are synthesized within the brain and act as endogenous anxiolytic,
anticonvulsant, hypnotic, and sedative agents, actions that are principally mediated via their …

This study examines how site-specific binding to three identified neurosteroid-binding sites
in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation …