[HTML][HTML] Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA
LL Chen, GG Carmichael - Molecular cell, 2009 - cell.com
In many cells, mRNAs containing inverted repeats (Alu repeats in humans) in their 3′
untranslated regions (3′ UTRs) are inefficiently exported to the cytoplasm. Nuclear …
untranslated regions (3′ UTRs) are inefficiently exported to the cytoplasm. Nuclear …
[HTML][HTML] An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles
NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in approximately 10 to 20
large foci that we show are completely coincident with paraspeckles, nuclear domains …
large foci that we show are completely coincident with paraspeckles, nuclear domains …
Alternative 3′‐end processing of long noncoding RNA initiates construction of nuclear paraspeckles
T Naganuma, S Nakagawa, A Tanigawa… - The EMBO …, 2012 - embopress.org
Paraspeckles are unique subnuclear structures built around a specific long noncoding RNA,
NEAT1, which is comprised of two isoforms produced by alternative 3′‐end processing …
NEAT1, which is comprised of two isoforms produced by alternative 3′‐end processing …
Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus
In many cells, mRNAs containing inverted repeated Alu elements (IR Alu s) in their 3′
untranslated regions (UTRs) are inefficiently exported to the cytoplasm. Such nuclear …
untranslated regions (UTRs) are inefficiently exported to the cytoplasm. Such nuclear …
TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes
While splicing has been shown to enhance nuclear export, it has remained unclear whether
mRNAs generated from intronless genes use specific machinery to promote their export …
mRNAs generated from intronless genes use specific machinery to promote their export …
[HTML][HTML] Sequence determinants for nuclear retention and cytoplasmic export of mRNAs and lncRNAs
AF Palazzo, ES Lee - Frontiers in genetics, 2018 - frontiersin.org
Eukaryotes are divided into two major compartments: the nucleus where RNA is synthesized
and processed, and the cytoplasm, where mRNA is translated into proteins. Although many …
and processed, and the cytoplasm, where mRNA is translated into proteins. Although many …
Paraspeckles: nuclear bodies built on long noncoding RNA
Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian
cell nuclei. These structures play a role in regulating the expression of certain genes in …
cell nuclei. These structures play a role in regulating the expression of certain genes in …
Nuclear retention of mRNAs–quality control, gene regulation and human disease
M Wegener, M Müller-McNicoll - Seminars in Cell & Developmental …, 2018 - Elsevier
Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously
underappreciated layer of gene regulation, which enables the cell to rapidly respond to …
underappreciated layer of gene regulation, which enables the cell to rapidly respond to …
Functional dissection of NEAT1 using genome editing reveals substantial localization of the NEAT1_1 isoform outside paraspeckles
Large numbers of long noncoding RNAs have been discovered in recent years, but only a
few have been characterized. NEAT1 (nuclear paraspeckle assembly transcript 1) is a …
few have been characterized. NEAT1 (nuclear paraspeckle assembly transcript 1) is a …
Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures
Nuclear paraspeckles are built co-transcriptionally around a long non-coding RNA, NEAT1.
Here we report that transfected 20-mer phosphorothioate-modified (PS) antisense …
Here we report that transfected 20-mer phosphorothioate-modified (PS) antisense …