Nucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis.
This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for …

Highlights•The eukaryotic replisome functions on chromatin, not just DNA, and interactions
with histones are critical for efficient replication.•Electron microscopy studies on the …

Eukaryotic replication disrupts each nucleosome as the fork passes, followed by reassembly
of disrupted nucleosomes and incorporation of newly synthesized histones into …

Efficient overcoming and accurate maintenance of chromatin structure and associated
histone marks during DNA replication are essential for normal functioning of the daughter …

In eukaryotic cells, histones are packaged into octameric core particles with DNA wrapping
around to form nucleosomes, which are the basic units of chromatin (Kornberg and Thomas …

DNA unwinding at eukaryotic replication forks displaces parental histones, which must be
redeposited onto nascent DNA in order to preserve chromatin structure. By screening …

The advance of replication forks to duplicate chromosomes in dividing cells requires the
disassembly of nucleosomes ahead of the fork and the rapid assembly of parental and de …

Chromatin structure governs a number of cellular processes including DNA replication,
transcription, and DNA repair. During DNA replication, chromatin structure including the …

During S phase, replicated DNA must be assembled into nucleosomes using both newly
synthesized and parental histones in a process that is tightly coupled to DNA replication …

The replisome is a protein complex on the DNA replication fork and functions in a dynamic
environment at the intersection of parental and nascent chromatin. Parental nucleosomes …