Inflammasome activation and pyroptotic cell death are known to contribute to the
pathogenesis of cardiovascular diseases, such as myocardial ischemia-reperfusion (I/R) …

Inflammation is a pivotal feature of myocardial reperfusion–induced microvascular injury and
dysfunction. However, the molecular mechanisms by which myocardial reperfusion triggered …

Abstract Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that recognises the double-
strand DNA. AIM2 inflammasome is a protein platform in the cell that initiates innate immune …

Coronary microembolization (CME) is a complicated problem that commonly arises in the
context of coronary angioplasty. The lncRNA taurine-up regulated gene 1 (TUG1) …

The NLRP3 inflammasome plays a key role in responding to pathogens, and endogenous
damage and mitochondria are intensively involved in inflammasome activation. The NLRP3 …

Abstract Background/aims The Nod-like receptor protein-3 (NLRP3) inflammasome
signalling pathway is involved in the inflammatory reaction of myocardial ischaemia …

Myocardial infarction is still a leading cause of morbidity and mortality worldwide, but its
pathogenesis has not been fully understood. In the study, we attempted to explore the effects …

Abstract Hypoxia/reoxygenation (H/R) induces pyroptosis in the setting of acute myocardial
infarction (AMI). Previous studies have shown that the expression of the miR-15 family is …

Objective The pathogenesis of acute pancreatitis mainly involves NLRP3 inflammasome-
mediated pancreatic cell injury, although regulators of this inflammasome machinery are still …

Background Acute myocardial infarction (AMI) is one of the leading causes of cardiovascular
morbidity and mortality worldwide. Pyroptosis is a form of inflammatory cell death that plays …