Breast cancer stem cells (BCSCs), which can fully recapitulate the tumor origin and are often
resistant to chemotherapy and radiotherapy, are currently considered as a major obstacle for …

Conventional chemotherapy drugs such as paclitaxel (PTX) can effectively inhibit tumor
growth by killing the majority of the proliferating cancer cells; however, it also results in multi …

Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. A
polymer-lipid supported mesoporous silica nanoparticle (PLS-MSNs) is described here to …

In this study, novel hyaluronic acid-pH stimuli-responsive lipid membrane mesoporous silica
nanoparticles (HA-PL-MSNs) were designed and assembled, with the chemotherapeutic …

Multidrug resistance (MDR) of cancer stem cells (CSCs) is a major hurdle to chemotherapy,
and it is very important to develop CSCs-specific targeted nanocarriers for the treatment of …

In this paper, a CD44-targeted and redox-responsive drug delivery system based on
mesoporous silica nanoparticles (MSNs) was synthesized by conjugating tumor-shedable …

Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity
and large functionalizable surface area for target-directed delivery. In this study, a series of …

Multidrug resistance is a major impediment for the successful chemotherapy in breast
cancer. CD44 is over-expressed in multidrug resistant human breast cancer cells. CD44 …

In an effort to enhance the antitumor efficacy of breast cancer treatment, the
chemotherapeutic agent Paclitaxel (PTX) was encapsulated within hyaluronic acid (HA) …

Investigation of potential therapeutics for targeting breast cancer stem cells (BCSCs) is
important because these cells are regarded as culprit of breast cancer relapse …