Although loss of cholinergic neurons in the basal forebrain is considered a key initial feature
in Alzheimer's disease (AD), changes in other transmitter systems, including serotonin and 5 …

Alzheimer's disease (AD) is associated with degeneration of cholinergic neurons in the
basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model …

Activation of serotonin 5-HT 4 receptors has pro-cognitive effects on memory performance.
The proposed underlying neurochemical mechanism is the enhancement of acetylcholine …

The possible involvement of 5-HT4 receptors in cognitive function was investigated with a
view toward modulating the cholinergic neuronal system. For this purpose, behavioral …

HT 4 receptor (5-HT 4 R) activation induces procognitive effects. This might be related to
stimulation of hippocampal acetylcholine release, which has been shown for 5-HT 4 R …

The present study was designed to investigate the distribution of serotonin 5-HT1A receptor
protein (5-HT1A-immunoreactivity) and its localization within cortical pyramidal neurons of …

Lesioning of serotonergic afferents increases hippocampal ACh release and attenuates
memory deficits produced by cholinergic lesions. Improved memory performance described …

The cholinergic system has been widely implicated in cognitive processes and cholinergic
loss is a classical hallmark in Alzheimer disease. Increasing evidence supports a role of the …

The effect of the serotonergic 5-HT 4 receptor agonists BIMU 1 and BIMU 8 onin
vivoacetylcholine (ACh) release in brain hemispheric regions of freely moving rats was …

Degeneration of cholinergic neurons in the basal forebrain (CBF) is a prominent
neuropathological feature of Alzheimer's disease and is thought responsible for some …