[HTML][HTML] STING senses microbial viability to orchestrate stress-mediated autophagy of the endoplasmic reticulum
Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity
and comprises primordial innate defense. Phagocytes mobilize interferon-inducible …
and comprises primordial innate defense. Phagocytes mobilize interferon-inducible …
STING directly activates autophagy to tune the innate immune response
STING (stimulator of interferon genes) is a central molecule that binds to cyclic dinucleotides
produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against …
produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against …
The STING1 network regulates autophagy and cell death
Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagy
W Wan, C Qian, Q Wang, J Li, H Zhang, L Wang… - The EMBO …, 2023 - embopress.org
The cGAS‐STING pathway plays an important role in host defense by sensing pathogen
DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of …
DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of …
Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation
M Jia, Y Wang, J Wang, D Qin, M Wang, L Chai… - Nature …, 2023 - nature.com
Stimulator of interferon gene (STING)-triggered autophagy is crucial for the host to eliminate
invading pathogens and serves as a self-limiting mechanism of STING-induced interferon …
invading pathogens and serves as a self-limiting mechanism of STING-induced interferon …
Inflammation-induced, STING-dependent autophagy restricts Zika virus infection in the Drosophila brain
Y Liu, B Gordesky-Gold, M Leney-Greene… - Cell host & …, 2018 - cell.com
The emerging arthropod-borne flavivirus Zika virus (ZIKV) is associated with neurological
complications. Innate immunity is essential for the control of virus infection, but the innate …
complications. Innate immunity is essential for the control of virus infection, but the innate …
Trafficking-mediated STING degradation requires sorting to acidified endolysosomes and can be targeted to enhance anti-tumor response
VK Gonugunta, T Sakai, V Pokatayev, K Yang, J Wu… - Cell reports, 2017 - cell.com
STING is an endoplasmic reticulum (ER)-associated transmembrane protein that turns on
and quickly turns off downstream signaling as it translocates from the ER to vesicles. How …
and quickly turns off downstream signaling as it translocates from the ER to vesicles. How …
STING controls energy stress-induced autophagy and energy metabolism via STX17
The stimulator of interferon genes (STING) plays a critical role in innate immunity. Emerging
evidence suggests that STING is important for DNA or cGAMP-induced non-canonical …
evidence suggests that STING is important for DNA or cGAMP-induced non-canonical …
The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
T Chen, Y Feng, W Sun, G Zhao, H Wu, X Cheng… - Immunity, 2023 - cell.com
STING (stimulator of interferon genes) exerts protective cellular responses to viral infection
via induction of interferon production and autophagy. Here, we report the role of STING in …
via induction of interferon production and autophagy. Here, we report the role of STING in …
A conserved ion channel function of STING mediates noncanonical autophagy and cell death
The cGAS/STING pathway triggers inflammation upon diverse cellular stresses such as
infection, cellular damage, aging, and diseases. STING also triggers noncanonical …
infection, cellular damage, aging, and diseases. STING also triggers noncanonical …