Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2
Abstract The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain
and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 …
and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 …
Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal
One of the major virulence factors of SARS-CoV-2, NSP1, is a vital drug target due to its role
in host immune evasion through multiple pathways. NSP1 protein is associated with …
in host immune evasion through multiple pathways. NSP1 protein is associated with …
SARS-CoV-2 nucleocapsid and Nsp3 binding: an in silico study
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) belongs to the single-stranded
positive-sense RNA family. The virus contains a large genome that encodes four structural …
positive-sense RNA family. The virus contains a large genome that encodes four structural …
Modelling studies reveal the importance of the C-terminal inter motif loop of NSP1 as a promising target site for drug discovery and screening of potential …
D Prabhu, S Rajamanikandan, M Sureshan… - Journal of Molecular …, 2021 - Elsevier
COVID-19 pandemic causative SARS-CoV-2 coronavirus is still rapid in progression and
transmission even after a year. Understanding the viral transmission and impeding the …
transmission even after a year. Understanding the viral transmission and impeding the …
Lysine 164 is critical for SARS-CoV-2 Nsp1 inhibition of host gene expression
Z Shen, G Zhang, Y Yang, M Li… - Journal of General …, 2021 - microbiologyresearch.org
The emerging pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has caused social and economic disruption worldwide, infecting over 9.0 million people and …
has caused social and economic disruption worldwide, infecting over 9.0 million people and …
Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: an in silico structure-based approach
In this study, the Nsp12–Nsp8 complex of SARS-CoV-2 was targeted with structure-based
and computer-aided drug design approach because of its vital role in viral replication …
and computer-aided drug design approach because of its vital role in viral replication …
Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography
A Borsatto, O Akkad, I Galdadas, S Ma, S Damfo… - Elife, 2022 - elifesciences.org
Non-structural protein 1 (Nsp1) is a main pathogenicity factor of α-and β-coronaviruses.
Nsp1 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suppresses the …
Nsp1 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suppresses the …
A computational approach for rational discovery of inhibitors for non-structural protein 1 of SARS-CoV-2
Abstract Background Non-structural protein 1 (Nsp1), a virulence agent of SARS-CoV-2, has
emerged as an important target for drug discovery. Nsp1 shuts down the host gene function …
emerged as an important target for drug discovery. Nsp1 shuts down the host gene function …
Structure of the SARS-CoV-2 Nsp1/5′-untranslated region complex and implications for potential therapeutic targets, a vaccine, and virulence
N Vankadari, NN Jeyasankar… - The journal of physical …, 2020 - ACS Publications
SARS-CoV-2 is the cause of the ongoing Coronavirus disease 19 (COVID-19) pandemic
around the world causing pneumonia and lower respiratory tract infections. In understanding …
around the world causing pneumonia and lower respiratory tract infections. In understanding …
Prediction of potential inhibitors against SARS-CoV-2 endoribonuclease: RNA immunity sensing
NAM Al-Rashedi, MG Munahi… - Journal of Biomolecular …, 2022 - Taylor & Francis
Abstract The World Health Organization has classified the COVID-19 outbreak a pandemic
which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and …
which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and …