Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein
M Yalcinkaya, W Liu, MN Islam, AG Kotini… - Scientific reports, 2021 - nature.com
Despite the initial success of some drugs and vaccines targeting COVID-19, understanding
the mechanism underlying SARS-CoV-2 disease pathogenesis remains crucial for the …
the mechanism underlying SARS-CoV-2 disease pathogenesis remains crucial for the …
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
TS Rodrigues, DS Zamboni - Current Opinion in Immunology, 2023 - Elsevier
Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …
Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice
J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …
great threat to global public health since 2020. Although the advance on vaccine …
[HTML][HTML] NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity
NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …
innate immune responses. The deleterious effects of inflammasome activation have been …
Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
SARS-CoV-2 nonstructural proteins 1 and 13 suppress caspase-1 and the NLRP3 inflammasome activation
NE Kim, DK Kim, YJ Song - Microorganisms, 2021 - mdpi.com
Viral infection-induced activation of inflammasome complexes has both positive and
negative effects on the host. Proper activation of inflammasome complexes induces down …
negative effects on the host. Proper activation of inflammasome complexes induces down …
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …
Novel coronavirus-induced NLRP3 inflammasome activation: a potential drug target in the treatment of COVID-19
A Shah - Frontiers in immunology, 2020 - frontiersin.org
Novel coronaviruses (nCoVs) encode ion-channel proteins called viroporins such as protein
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …
Severe COVID-19: NLRP3 inflammasome dysregulated
DF Van den Berg, AA Te Velde - Frontiers in immunology, 2020 - frontiersin.org
SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous
adjuvant activity necessary to mount a proper adaptive immune response against the virus …
adjuvant activity necessary to mount a proper adaptive immune response against the virus …
Targeting the NLRP3 inflammasome in severe COVID-19
TL Freeman, TH Swartz - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …
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