The neurobiology of bipolar disorder, a chronic and systemic ailment is not completely
understood. The bipolar phenotype manifests in myriad ways, and psychopharmacological …

The Wnt signaling pathway is a highly conserved pathway critical for proper embryonic
development. However, recent evidence suggests that this pathway and one of its key …

Background: Bipolar disorder (BD) is a debilitating mental ailment characterized by recurrent
episodes of mania and depression. Primary mood-stabilizing drugs like lithium and …

The canonical Wnt signaling pathway is critical for development of the mammalian central
nervous system and regulates diverse processes throughout adulthood, including adult …

Bipolar disorder is a serious psychiatric condition that has been treated for over 50 years
with lithium. Lithium is a well established glycogen synthase kinase-3 (GSK-3) inhibitor …

The neurobiology of Bipolar Disorder (BD) is not completely understood, although
abnormalities in neuroplasticity and control of apoptosis have been considered as central …

Objective. To discuss the link between glycogen synthase kinase‐3 (GSK3) and the main
biological alterations demonstrated in bipolar disorder (BD), with special attention to the …

Lithium is the most effective and well established treatment for bipolar disorder, and it has a
broad array of effects within cellular pathways. However, the specific processes through …

Regulation of complex signaling pathways plays a critical role in higher-order brain
functions including the regulation of mood, cognition, appetite, sexual arousal, sleep …

The enzyme glycogen synthase kinase-3 (GSK-3) is a direct target of lithium. While originally
recognized as an important molecule in a limited number of cellular processes, with unclear …