Mass spectrometry-based determination of lipids and small molecules composing adipose tissue with a focus on brown adipose tissue

K Miniewska, J Godzien, P Mojsak… - … of Pharmaceutical and …, 2020 - Elsevier
Adipose tissue has been the subject of research for a very long time. Many studies perform a
comprehensive analysis of different types of adipose tissue with an emphasis on brown …

Human white adipose tissue metabolome: Current perspective

J Kučera, Z Spáčil, D Friedecký, J Novák, M Pekař… - …, 2018 - Wiley Online Library
Objective Interest in metabolites produced by adipose tissue has increased substantially in
the past several decades. Previously regarded as an inert energy storage depot, adipose …

Sample preparation methods for lipidomics approaches used in studies of obesity

I Liakh, T Sledzinski, L Kaska, P Mozolewska, A Mika - Molecules, 2020 - mdpi.com
Obesity is associated with alterations in the composition and amounts of lipids. Lipids have
over 1.7 million representatives. Most lipid groups differ in composition, properties and …

Application of lipidomics and metabolomics to the study of adipose tissue

I Mattila, T Seppänen-Laakso, T Suortti… - Adipose Tissue …, 2008 - Springer
Role of specific reactive lipids as well as amino acids in control of insulin signalling in
adipose tissue is well recognized. Since it is practically impossible to measure the levels of …

Mass spectrometry-based metabolomics analysis of obese patients' blood plasma

PG Lokhov, EE Balashova, OP Trifonova… - International journal of …, 2020 - mdpi.com
Scientists currently use only a small portion of the information contained in the blood
metabolome. The identification of metabolites is a huge challenge because only highly …

[HTML][HTML] Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

M Grzybek, A Palladini, VI Alexaki, MA Surma… - Molecular …, 2019 - Elsevier
Objective Shotgun lipidomics enables an extensive analysis of lipids from tissues and fluids.
Each specimen requires appropriate extraction and processing procedures to ensure good …

Minor lipids profiling in subcutaneous and epicardial fat tissue using LC/MS with an optimized preanalytical phase

P Tomášová, M Čermáková, H Pelantová… - … of Chromatography B, 2019 - Elsevier
Abstract Analysis of bioactive lipids in adipose tissue could lead to better understanding of
the pathogenesis of obesity and its complications. However, current MS methods are limited …

A review of structural features, biological functions and biotransformation studies in adipose tissues and an assessment of Progress and implications

T Chu, MS Yang - … Metabolic & Immune Disorders-Drug Targets …, 2023 - ingentaconnect.com
Roles for adipose tissues in energy metabolism, health maintenance and disease onset
have been established. Evidence indicates that white, brown and beige fats are quite …

Differences in the metabolic profiles of brown and white adipocytes based on secretomics

Z Zhang, X Liao, X Guo, J Gao - Biochemical and Biophysical Research …, 2023 - Elsevier
Brown adipocytes and white adipocytes play important roles in systemic metabolism and
energy homeostasis. Recent studies have demonstrated that white adipocytes and brown …

Comprehensive proteomics and functional annotation of mouse brown adipose tissue

J Li, J Li, WG Zhao, HD Sun, ZG Guo, XY Liu… - PLoS …, 2020 - journals.plos.org
Knowledge about the mouse brown adipose tissue (BAT) proteome can provide a deeper
understanding of the function of mammalian BAT. Herein, a comprehensive analysis of …