As a model of lipid rafts, the liquid-ordered (Lo) phase formed by sphingomyelin (SM) and
cholesterol (Cho) in bilayer membranes has long attracted the attention of biophysics …

Lipids segregate with each other into small domains in biological membranes, which can
facilitate the associations of particular proteins. The segregation of cholesterol and …

The segregation of lipids into lateral membrane domains has been extensively studied. It is
well established that the structural differences between phospholipids play an important role …

The lateral organization of biomembranes has gained significant interest when the fluid
mosaic model was challenged by the model of “lipid rafts”. Several lipid classes like …

Mixtures of unsaturated lipids, sphingolipids, and cholesterol form coexisting liquid-
disordered and sphingolipid and cholesterol-rich liquid-ordered (Lo) phases in water. The …

Sphingolipid-and cholesterol-rich liquid-ordered (Lo) lipid domains (rafts) are thought to be
important organizing elements in eukaryotic plasma membranes. How they form in the …

Sphingomyelin (SM), a major component of small domains (or lipid rafts) in mammalian cell
membranes, forms a liquid-ordered phase in the presence of cholesterol (Cho). However …

The lipidome of mammalian cells not only contain sphingomyelin (SM) but also, as a minor
component, dihydrosphongomyelin (DHSM), in which the double bond at C4–C5 in the …

The existence of lipid rafts in biological membranes in vivo is still debated. In contrast, the
formation of domains in model systems has been well documented. In giant unilamellar …

Saturated sphingomyelin (SM) lipids are implicated in lipid rafts in cell plasma membranes.
Here we use fluorescence microscopy to observe coexisting liquid domains in vesicles …