For decades, lung cancer has been the leading cause of cancer-related death worldwide.
Hypoxia-inducible factors (HIFs) play critical roles in mediating lung cancer development …

Activation of hypoxia-inducible factor 1α (HIF1α) controls the transcription of genes
governing angiogenesis under hypoxic condition during tumorigenesis. Here we show that …

Objectives Feline sarcoma-related protein (FER) is known to play a critical regulatory role in
several carcinomas. However, the exact biological function of FER in hepatocellular …

Deregulated microRNAs (miRNAs) are small noncoding RNAs that are involved in the
carcinogenesis of various cancers, including lung cancer. HIF1α has been suggested to be …

The regulation of HIF-1α is considered to be realized by pVHL-mediated ubiquitin-26S
proteasome pathway at a post-transcriptional level. The discovery of a class of small …

Ferroportin (FPN) exports iron from duodenal enterocytes, macrophages, and hepatocytes to
maintain systemic iron homeostasis. In addition, FPN is expressed in various cancer cells …

Abstract Hypoxia-inducible factors (HIFs) 1 and 2 are dimeric α/β transcription factors that
regulate cellular responses to low oxygen. HIF-1 is induced first, whereas HIF-2 is …

The acquisition of the cancer stem cell (CSC) properties is often mediated by the
surrounding microenvironment, and tumor hypoxia is considered an important factor for CSC …

Hepatocellular carcinoma (HCC) is one of the most common solid tumors globally. Our
previous studies revealed that miR-627-5p suppresses HCC progression via targeting …

Hypoxia-inducible factors (HIFs) regulate cellular oxygen balance and play a central role in
cancer metastasis and angiogenesis. Despite extensive research on HIFs, successful …