Impact of everolimus plus calcineurin inhibitor on formation of non-HLA antibodies and graft outcomes in kidney transplant recipients: 12-month results from the …

A Philippe, W Arns, V Ditt, IA Hauser… - Frontiers in …, 2023 - frontiersin.org
Background Non-human leukocyte antigen (non-HLA) antibodies including antibodies
targeting Angiotensin II type 1 (AT1R) and Endothelin-1 type A (ETAR) receptors represent a …

Everolimus plus reduced calcineurin inhibitor prevents de novo anti-HLA antibodies and humoral rejection in kidney transplant recipients: 12-month results from the …

W Arns, A Philippe, V Ditt, IA Hauser… - Frontiers in …, 2023 - frontiersin.org
Background Studies prospectively monitoring de novo donor-specific antibodies (dnDSAs)
and their clinical impact are sparse. This substudy of ATHENA was initiated to evaluate the …

Efficacy and safety of everolimus for maintenance immunosuppression of kidney transplantation: a meta-analysis of randomized controlled trials

J Liu, D Liu, J Li, L Zhu, C Zhang, K Lei, Q Xu, R You - PloS one, 2017 - journals.plos.org
Background Conversion to everolimus is often used in kidney transplantation to overcome
calcineurin inhibitor (CNI) nephrotoxicity but there is conflicting evidence for this approach …

[HTML][HTML] The impact of non-HLA antibodies directed against endothelin-1 type A receptors (ETAR) on early renal transplant outcomes

M Banasik, M Boratyńska, K Kościelska-Kasprzak… - Transplant …, 2014 - Elsevier
Abstract Background Non-HLA antibodies (Abs) targeting vascular receptors are considered
to have an influence on renal transplant injury. Anti-endothelin-1 type A receptor (anti-ETAR) …

Evolution of donor‐specific antibodies (DSA) and incidence of de novo DSA in solid organ transplant recipients after switch to everolimus alone or associated with …

E Perbos, E Juinier, G Guidicelli, C Dromer… - Clinical …, 2014 - Wiley Online Library
Background Everolimus (EVR) is used in organ transplantation to minimize calcineurin
inhibitors (CNI). Some studies pointed out an increase in rejection and de novo donor …

De novo everolimus for recipients of kidney transplants from HLA identical donors

MP Cristelli, A Ferreira, P Hannun, C Felipe… - Brazilian Journal of …, 2016 - SciELO Brasil
Introduction: Kidney transplant recipients from HLA-identical living donor have lower risk of
acute rejection and greater graft survival compared to other types of kidney transplantation …

Early conversion from calcineurin inhibitor‐to everolimus‐based therapy following kidney transplantation: results of the randomized ELEVATE trial

JW de Fijter, H Holdaas, O Øyen… - American Journal of …, 2017 - Wiley Online Library
In a 24‐month, multicenter, open‐label, randomized trial, 715 de novo kidney transplant
recipients were randomized at 10–14 weeks to convert to everolimus (n= 359) or remain on …

Design and rationale of the ATHENA study–A 12-month, multicentre, prospective study evaluating the outcomes of a de novo everolimus-based regimen in …

C Sommerer, B Suwelack, D Dragun, P Schenker… - Trials, 2016 - Springer
Background Immunosuppression with calcineurin inhibitors remains the mainstay of
treatment after kidney transplantation; however, long-term use of these drugs may be …

Is pre‐transplant sensitization against angiotensin II type 1 receptor still a risk factor of graft and patient outcome in kidney transplantation in the anti‐HLA Luminex era …

C Deltombe, F Gillaizeau, D Anglicheau… - Transplant …, 2017 - Wiley Online Library
We aimed to assess the correlation of anti‐angiotensin II type 1 receptor antibodies (anti‐AT
1R‐Abs) before transplantation on a multicentric cohort of kidney transplant recipients (2008 …

Everolimus with reduced calcineurin inhibitor exposure in renal transplantation

J Pascual, SP Berger, O Witzke… - Journal of the …, 2018 - journals.lww.com
Background Everolimus permits reduced calcineurin inhibitor (CNI) exposure, but the
efficacy and safety outcomes of this treatment after kidney transplant require confirmation …