Abstract The Open Targets Platform integrates evidence from genetics, genomics,
transcriptomics, drugs, animal models and scientific literature to score and rank target …

Abstract The Open Targets Platform (https://platform. opentargets. org/) is an open source
resource to systematically assist drug target identification and prioritisation using publicly …

Abstract The Open Targets Platform (https://www. targetvalidation. org/) provides users with
a queryable knowledgebase and user interface to aid systematic target identification and …

Background Target identification and validation is a pressing challenge in the
pharmaceutical industry, with many of the programmes that fail for efficacy reasons showing …

We have designed and developed a data integration and visualization platform that provides
evidence about the association of known and potential drug targets with diseases. The …

There are at least two good reasons for the on-going interest in drug–target interactions: first,
drug-effects can only be fully understood by considering a complex network of interactions to …

Target identification (determining the correct drug targets for a disease) and target validation
(demonstrating an effect of target perturbation on disease biomarkers and disease end …

Prioritising candidate genes for further experimental characterisation is a non-trivial
challenge in drug discovery and biomedical research in general. An integrated approach …

A number of technologies, including CRISPR/Cas, transcription activator-like effector
nucleases and zinc-finger nucleases, allow the user to target a chosen locus for genome …

The molecular basis of drug action is often not well understood. This is partly because the
very abundant and diverse information generated in the past decades on drugs is hidden in …