When cultured at an air–liquid interface (ALI) in the appropriate medium, primary human
airway epithelial cells form a polarized, pseudostratified epithelium composed of ciliated and …

Human airway epithelial cells cultured in vitro at the air–liquid interface (ALI) form a
pseudostratified epithelium that forms tight junctions and cilia, and produces mucin. These …

Organotypic cultures of primary human airway epithelial cells have been used to investigate
the morphology, ion and fluid transport, innate immunity, transcytosis, infection …

Cell biological and molecular characterization of structural and functional ciliary components
and regulators of mammalian motile ciliogenesis is made possible by the development of a …

The epithelium that lines the conducting airways is composed of several distinct cell types
that differentiate from common progenitor cells. The signals that control fate selection and …

In vitro differentiation of airway epithelium is of interest for respiratory tissue engineering and
studying airway diseases. Both applications benefit from the use of primary cells to maintain …

The upper airway epithelium, which is mainly composed of multiciliated, goblet, club and
basal cells, ensures proper mucociliary function and can regenerate in response to assaults …

The human bronchial epithelium is an important barrier tissue that is damaged or
pathologically altered in various acute and chronic respiratory conditions. To represent the …

Mucous cell metaplasia is a hallmark of airway diseases, such as asthma and chronic
obstructive pulmonary disease. The majority of human airway epithelium is pseudostratified …

Cilia are traditionally classified as motile or primary. Motile cilia are restricted to specific
populations of well-differentiated epithelial cells, including those in the airway, brain …