[HTML][HTML] Biologically enhanced genome-wide association study provides further evidence for candidate loci and discovers novel loci that influence risk of anterior …
Anterior cruciate ligament (ACL) rupture is a common condition that disproportionately
affects young people, 50% of whom will develop knee osteoarthritis (OA) within 10 years of …
affects young people, 50% of whom will develop knee osteoarthritis (OA) within 10 years of …
[HTML][HTML] Multivariate genome-wide association analysis identifies novel and relevant variants associated with anterior cruciate ligament rupture risk in the dog model
Background Anterior cruciate ligament rupture (ACLR) is a debilitating and potentially life-
changing condition in humans, as there is a high prevalence of early-onset osteoarthritis …
changing condition in humans, as there is a high prevalence of early-onset osteoarthritis …
Bayesian and machine learning models for genomic prediction of anterior cruciate ligament rupture in the canine model
Anterior cruciate ligament (ACL) rupture is a common, debilitating condition that leads to
early-onset osteoarthritis and reduced quality of human life. ACL rupture is a complex …
early-onset osteoarthritis and reduced quality of human life. ACL rupture is a complex …
[HTML][HTML] Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture
Anterior cruciate ligament (ACL) rupture is a common condition that can be devastating and
life changing, particularly in young adults. A non-contact mechanism is typical. Second ACL …
life changing, particularly in young adults. A non-contact mechanism is typical. Second ACL …
[HTML][HTML] Analysis of copy number variation in dogs implicates genomic structural variation in the development of anterior cruciate ligament rupture
Anterior cruciate ligament (ACL) rupture is an important condition of the human knee.
Second ruptures are common and societal costs are substantial. Canine cranial cruciate …
Second ruptures are common and societal costs are substantial. Canine cranial cruciate …
[HTML][HTML] A whole genome sequencing approach to anterior cruciate ligament rupture–a twin study in two unrelated families
D Feldmann, CD Bope, J Patricios, ER Chimusa… - Plos one, 2022 - journals.plos.org
Predisposition to anterior cruciate ligament (ACL) rupture is multi-factorial, with variation in
the genome considered a key intrinsic risk factor. Most implicated loci have been identified …
the genome considered a key intrinsic risk factor. Most implicated loci have been identified …
[HTML][HTML] Gene expression profiling of normal and ruptured canine anterior cruciate ligaments
OBJECTIVE: To identify genes which may be involved in the development of anterior
cruciate ligament (ACL) laxity and rupture in a naturally occurring canine osteoarthritis (OA) …
cruciate ligament (ACL) laxity and rupture in a naturally occurring canine osteoarthritis (OA) …
[HTML][HTML] Genome-Wide Association Screens for Anterior Cruciate Ligament Tears
V Candela, UG Longo, A Berton, G Salvatore… - Journal of Clinical …, 2024 - mdpi.com
Background: The etiopathogenesis of ACL rupture is not clarified. The aim of this study is to
identify genomic regions and genetic variants relevant to anterior cruciate ligament injury …
identify genomic regions and genetic variants relevant to anterior cruciate ligament injury …
[HTML][HTML] Three genes associated with anterior and posterior cruciate ligament injury: a genome-wide association analysis
SK Kim, C Nguyen, AL Avins, GD Abrams - Bone & Joint Open, 2021 - boneandjoint.org.uk
Aims The aim of this study was to screen the entire genome for genetic markers associated
with risk for anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) injury …
with risk for anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) injury …
Interactions between collagen gene variants and risk of anterior cruciate ligament rupture
K O'Connell, H Knight, K Ficek… - European journal of …, 2015 - Taylor & Francis
Abstract The COL5A1 and COL12A1 variants are independently associated with modulating
the risk of anterior cruciate ligament (ACL) rupture in females. The objective of this study was …
the risk of anterior cruciate ligament (ACL) rupture in females. The objective of this study was …
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