Carbonic anhydrases (CAs) catalyze a reaction fundamental for life: the bidirectional
conversion of carbon dioxide (CO2) and water (H2O) into bicarbonate (HCO3−) and protons …

Carbonic anhydrases (CAs) have not only been identified as ubiquitous enzymes catalyzing
the fast reversible hydration of carbon dioxide to generate or consume protons and …

By catalysing a very simple physiological reaction, the hydration of carbon dioxide (CO2) to
bicarbonate (HCO3-) and a proton (H+), carbonic anhydrases (CAs), of which five …

The energetics of proton transfer reactions in carbonic anhydrase (CA) have been studied
with an active site model. Specifically, proton transfer from a zinc-bound water molecule to a …

While the carbonic anhydrase (CA, EC 4.2. 1.1) superfamily of enzymes has been described
primarily as involved only in pH regulation for decades, it also has many other important …

Carbonic anhydrases are a widely expressed family of enzymes that catalyze the reversible
reaction: CO2+ H2O HCO3-+ H+. These enzymes therefore both produce HCO3-for …

During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

Recent QM/MM analyses of proton transfer function of human carbonic anhydrase II (CAII)
are briefly reviewed. The topics include a preliminary analysis of nuclear quadrupole …

H+ ions are remarkably efficient modulators of neuronal excitability. This renders brain
functions highly sensitive to small changes in pH which are generated “extrinsically” via …

The enzyme carbonic anhydrase (CA) catalyzes the reversible hydration/dehydration of CO2
and water, maintaining a near-instantaneous equilibrium among all chemical species …