Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
[HTML][HTML] KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation
Abstract KMT2D (lysine (K)-specific methyltransferase 2D), formerly named MLL2
(myeloid/lymphoid or mixed-lineage leukemia 2, also known as ALR/MLL4), is a histone …
(myeloid/lymphoid or mixed-lineage leukemia 2, also known as ALR/MLL4), is a histone …
COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer
RJ Fagan, AK Dingwall - Cancer letters, 2019 - Elsevier
The KMT2 (lysine methyltransferase) family of histone modifying proteins play essential
roles in regulating developmental pathways, and mutations in the genes encoding these …
roles in regulating developmental pathways, and mutations in the genes encoding these …
The cancer COMPASS: navigating the functions of MLL complexes in cancer
DJ Ford, AK Dingwall - Cancer genetics, 2015 - Elsevier
The mixed-lineage leukemia family of histone methyltransferases (MLL1–4, or KMT2A–D)
were previously linked to cancer through the founding member, MLL1/KMT2A, which is often …
were previously linked to cancer through the founding member, MLL1/KMT2A, which is often …
Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention
Aberrant histone lysine methylation that is controlled by histone lysine methyltransferases
(KMTs) and demethylases (KDMs) plays significant roles in carcinogenesis. Infections by …
(KMTs) and demethylases (KDMs) plays significant roles in carcinogenesis. Infections by …
[HTML][HTML] Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors
SS Dhar, MG Lee - Oncotarget, 2021 - ncbi.nlm.nih.gov
Epigenetic mechanisms are central to understanding the molecular basis underlying
tumorigenesis. Aberrations in epigenetic modifiers alter epigenomic landscapes and play a …
tumorigenesis. Aberrations in epigenetic modifiers alter epigenomic landscapes and play a …
Histone lysine methyltransferases in biology and disease
D Husmann, O Gozani - Nature structural & molecular biology, 2019 - nature.com
The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …
the epigenome regulates virtually all DNA-templated processes. A large number of histone …
MLL5 (KMT2E): structure, function, and clinical relevance
X Zhang, W Novera, Y Zhang, LW Deng - Cellular and molecular life …, 2017 - Springer
The mixed lineage leukemia (MLL) family of genes, also known as the lysine N-
methyltransferase 2 (KMT2) family, are homologous to the evolutionarily conserved trithorax …
methyltransferase 2 (KMT2) family, are homologous to the evolutionarily conserved trithorax …
[HTML][HTML] Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia
Here we report a comprehensive characterization of our recently developed inhibitor MM-
401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is able to specifically …
401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is able to specifically …
Substrate and product specificities of SET domain methyltransferases
PA Del Rizzo, RC Trievel - Epigenetics, 2011 - Taylor & Francis
SET domain lysine methyltransferases (KMTs) catalyze the site-and state-specific
methylation of lysine residues in histone and non-histone substrates. These modifications …
methylation of lysine residues in histone and non-histone substrates. These modifications …