AIM: To summarize the major findings of the five Cochrane reviews on substitution
maintenance treatments for opioid dependence. METHODS: We conducted a narrative and …

Background Methadone maintenance was the first widely used opioid replacement therapy
to treat heroin dependence, and it remains the best‐researched treatment for this problem …

Background Methadone maintenance treatment (MMT) is a long term opiod replacement
therapy, effective in the management of opiod dependence. Even if MMT at high dosage is …

Background Several types of medications have been used for stabilizing heroin users:
Methadone, Buprenorphine and levo‐alpha‐acetyl‐methadol (LAAM.) The present review …

Illicit use of opiates is the fastest growing substance use problem in the United States, and
the main reason for seeking addiction treatment services for illicit drug use throughout the …

Background Maintenance treatments are effective in retaining patients in treatment and
suppressing heroin use. Questions remain regarding the efficacy of additional psychosocial …

Background Retention in opioid substitution (OST) treatment is associated with substantial
reductions in all cause and overdose mortality. This systematic review aims to identify both …

Background LAAM and methadone are both opiate agonists and have been shown to
reduce dependence on heroin when given continuously under supervised dosing …

Background Opioid substitution treatments are effective in retaining people in treatment and
suppressing heroin use. An open question remains whether slow‐release oral morphine …

The efficacy of methadone maintenance in opioid addiction was assessed in terms of
programme retention rate and reduction of illicit opioid use by means of a meta-analysis of …