Channeling carbohydrates and fatty acids to thermogenic tissues, including brown and
beige adipocytes, have garnered interest as an approach for the management of obesity …

Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN)
in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte …

Owing to its unique capacity to clear macronutrients from circulation and use them to
produce heat, thermogenic fat is capable of regulating glucose, lipids, and branched-chain …

Long-chain acyl-CoA synthetase-1 (ACSL1) contributes 80% of total ACSL activity in
adipose tissue and was believed to be essential for the synthesis of triacylglycerol. We …

The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and
improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat …

During the last decade, significant progress has been made in understanding adipocytes
with a particular focus on thermogenic fat cells, which effectively convert chemical energy …

Fatty acids are essential contributors to adipocyte-based non-shivering thermogenesis by
acting as activators of uncoupling protein 1 and serving as fuel for mitochondrial heat …

Acyl-CoA thioesterases (ACOTs) are enzymes that catalyze the hydrolysis of fatty acyl-CoAs
to free fatty acids and CoA-SH. In this study, we show that the expression profile of the ACOT …

Adipose thermogenesis is the energy lost as heat through metabolism of macronutrients in
specialized fat cells, or adipocytes. This program is activated by neuronal, hormonal, and …

Adipocyte biology has been intensely researched in recent years due to the emergence of
obesity as a serious global health concern and because of the realization that adipose …