Non-targeted effects (NTE) have been generally regarded as a low-dose ionizing radiation
(IR) phenomenon. Recently, regarding long distant abscopal effects have also been …

Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

It has been more than 60 years since the discovery of the oxygen effect that empirically
demonstrates the direct association between cell radiosensitivity and oxygen tension …

The role of mitochondria in cancer formation and progression has been studied extensively,
but much remains to be understood about this complex relationship. Mitochondria regulate …

The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …

Cancer cells adapt to increasing energy and biosynthetic demands by reprogramming their
metabolic pathways. Mitochondria are important organelles for the metabolic …

Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria
are essential organelles responsible for numerous physiologic processes, such as energy …

Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to
elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane …

During tissue injury events, the innate immune system responds immediately to alarms sent
from the injured cells, and the adaptive immune system subsequently joins in the …

Exposure to ionizing radiation (IR) induces various types of DNA damage, of which DNA
double-strand breaks are the most severe, leading to genomic instability, tumorigenesis, and …