Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies
X Xiao, S Huang, S Chen, Y Wang, Q Sun… - Journal of Experimental & …, 2021 - Springer
Chimeric antigen receptor (CAR) T-cell therapy has yielded impressive outcomes and
transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell …
transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell …
In the eye of the storm: immune-mediated toxicities associated with CAR-T cell therapy
JG Borrega, P Gödel, MA Rüger, ÖA Onur… - …, 2019 - journals.lww.com
The success of chimeric antigen receptor (CAR)-T cell therapy with impressive response
rates in hematologic malignancies but also promising data in solid tumors came along with …
rates in hematologic malignancies but also promising data in solid tumors came along with …
Management of cytokine release syndrome and neurotoxicity in chimeric antigen receptor (CAR) T cell therapy
UH Acharya, T Dhawale, S Yun… - Expert Review of …, 2019 - Taylor & Francis
Introduction: Chimeric antigen receptor (CAR) T cell immunotherapy has demonstrated
remarkable anti-tumor activity in B-cell malignancies and is under investigation in other …
remarkable anti-tumor activity in B-cell malignancies and is under investigation in other …
The pathogenesis, diagnosis, prevention, and treatment of CAR-T cell therapy-related adverse reactions
Y Li, Y Ming, R Fu, C Li, Y Wu, T Jiang, Z Li… - Frontiers in …, 2022 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy is effective in the treatment of
refractory/relapsed (r/r) hematological malignancies (r/r B-cell lymphoblastic leukemia, B-cell …
refractory/relapsed (r/r) hematological malignancies (r/r B-cell lymphoblastic leukemia, B-cell …
[HTML][HTML] Immune effector cell associated neurotoxicity syndrome in chimeric antigen receptor-T cell therapy
RC Sterner, RM Sterner - Frontiers in immunology, 2022 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy is an emerging staple in the treatment of
certain hematological malignancies. While CAR-T cells have produced robust responses in …
certain hematological malignancies. While CAR-T cells have produced robust responses in …
Toward better understanding and management of CAR-T cell–associated toxicity
Adoptive transfer of T cells modified with chimeric antigen receptors (CAR-T cells) has
changed the therapeutic landscape of hematological malignancies, particularly for acute …
changed the therapeutic landscape of hematological malignancies, particularly for acute …
Current approaches in the grading and management of cytokine release syndrome after chimeric antigen receptor T-cell therapy
LL Riegler, GP Jones, DW Lee - Therapeutics and clinical risk …, 2019 - Taylor & Francis
With immunotherapy innovations for cancer treatment, in particular chimeric antigen receptor
(CAR) T cells, becoming more successful and prevalent, strategies to mitigate and manage …
(CAR) T cells, becoming more successful and prevalent, strategies to mitigate and manage …
[HTML][HTML] Side-effect management of chimeric antigen receptor (CAR) T-cell therapy
Highlights•CAR T cells are associated with unique side-effects.•Cytokine release syndrome
(CRS), immune effector cell-associated neurotoxicity syndrome (ICANS) and cytopenias are …
(CRS), immune effector cell-associated neurotoxicity syndrome (ICANS) and cytopenias are …
CAR-T cell therapy: the efficacy and toxicity balance
KL Chohan, EL Siegler, SS Kenderian - Current hematologic malignancy …, 2023 - Springer
Abstract Purpose of Review Chimeric antigen receptor (CAR) T cell therapy is an
immunotherapy that has resulted in tremendous progress in the treatment of patients with B …
immunotherapy that has resulted in tremendous progress in the treatment of patients with B …
The biological basis and clinical symptoms of CAR-T therapy-associated toxicites
A Titov, A Petukhov, A Staliarova, D Motorin… - Cell death & …, 2018 - nature.com
Currently, immunotherapy is attracting a lot of attention and may potentially become a
leading approach in the treatment of cancer. One emerging therapeutic, the chimeric …
leading approach in the treatment of cancer. One emerging therapeutic, the chimeric …