Mesenchymal stem cell-derived microvesicles protect against acute tubular injury

S Bruno, C Grange, MC Deregibus… - Journal of the …, 2009 - journals.lww.com
Administration of mesenchymal stem cells (MSCs) improves the recovery from acute kidney
injury (AKI). The mechanism may involve paracrine factors promoting proliferation of …

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia–reperfusion-induced acute and chronic kidney injury

S Gatti, S Bruno, MC Deregibus, A Sordi… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. Several studies demonstrated that mesenchymal stem cells (MSCs) reverse
acute kidney injury (AKI) by a paracrine mechanism rather than by MSC transdifferentiation …

[HTML][HTML] Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury

S Bruno, C Grange, F Collino, MC Deregibus… - PloS one, 2012 - journals.plos.org
Several studies demonstrated that treatment with mesenchymal stem cells (MSCs) reduces
cisplatin mortality in mice. Microvesicles (MVs) released from MSCs were previously shown …

Therapeutic potential of mesenchymal stem cell-derived microvesicles

L Biancone, S Bruno, MC Deregibus… - Nephrology Dialysis …, 2012 - academic.oup.com
Several studies have demonstrated that mesenchymal stem cells have the capacity to
reverse acute and chronic kidney injury in different experimental models by paracrine …

[HTML][HTML] Microparticles from kidney-derived mesenchymal stem cells act as carriers of proangiogenic signals and contribute to recovery from acute kidney injury

HY Choi, SJ Moon, BB Ratliff, SH Ahn, A Jung, M Lee… - PloS one, 2014 - journals.plos.org
We recently demonstrated the use of in vitro expanded kidney-derived mesenchymal stem
cells (KMSC) protected peritubular capillary endothelial cells in acute renal ischemia …

Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury

F Tögel, A Cohen, P Zhang, Y Yang, Z Hu… - Stem cells and …, 2009 - liebertpub.com
Acute kidney injury (AKI) is a major clinical problem associated with high morbidity and
mortality. Likely due to its complex pathophysiology, therapies with a single pharmacological …

[HTML][HTML] Mesenchymal stem cells, not conditioned medium, contribute to kidney repair after ischemia-reperfusion injury

L Xing, R Cui, L Peng, J Ma, X Chen, RJ Xie… - Stem cell research & …, 2014 - Springer
Introduction Studies have shown that stem cells exert their therapeutic effects on acute
kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in …

Bone marrow stem cells‐derived microvesicles protect against renal injury in the mouse remnant kidney model

J He, Y Wang, S Sun, M Yu, C Wang, X Pei, B Zhu… - …, 2012 - Wiley Online Library
Aims: Several studies have demonstrated administration of mesenchymal stem cells (MSC)
could reverse kidney injury by paracrine mechanisms rather than by MSC …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges

A Aghajani Nargesi, LO Lerman, A Eirin - Stem cell research & therapy, 2017 - Springer
Novel therapies are urgently needed to address the rising incidence and prevalence of
acute kidney injury (AKI) and chronic kidney disease (CKD). Mesenchymal stem/stromal …

Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice

M Morigi, M Introna, B Imberti, D Corna, M Abbate… - Stem …, 2008 - academic.oup.com
Transplantation of bone marrow mesenchymal stem cells (BM-MSC) or stromal cells from
rodents has been identified as a strategy for renal repair in experimental models of acute …