The emergence of drug-resistant strains of Mycobacterium tuberculosis is a challenge to
global tuberculosis (TB) control. Although culture-based methods have been regarded as …

Drug-resistant tuberculosis is a substantial health-care concern worldwide. Despite culture-
based methods being considered the gold standard for drug susceptibility testing, molecular …

Abstract Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and
control programmes worldwide. Advances in sequencing technology have significantly …

Drug resistance (DR) remains a major challenge for tuberculosis (TB) control. Whole-
genome sequencing (WGS) provides the highest genetic resolution for genotypic drug …

Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium
tuberculosis (Mtb), has burdened vulnerable populations in modern day societies for …

Background Rapid molecular diagnostics for detecting multidrug-resistant and extensively
drug-resistant tuberculosis (M/XDR-TB) primarily identify mutations in Mycobacterium …

Drug-resistant tuberculosis (DR-TB), including multi-and extensively drug-resistant TB, is
posing a significant challenge to effective treatment and TB control worldwide. New progress …

Resistance to antimycobacterial drugs is a major barrier to effective treatment of
Mycobacterium tuberculosis infection. Molecular diagnostic techniques based on the …

Background Tuberculosis (TB) incidence and mortality are declining worldwide; however,
poor detection of drug-resistant disease threatens to reverse current progress toward global …

Routine whole genome sequencing (WGS) of pathogens is becoming more feasible as
sequencing costs decrease and access to benchtop sequencing equipment and …