Is the brain macroscopically linear? A system identification of resting state dynamics

E Nozari, MA Bertolero, J Stiso, L Caciagli… - arXiv preprint arXiv …, 2020 - arxiv.org
A central challenge in the computational modeling of neural dynamics is the trade-off
between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are …

Macroscopic resting-state brain dynamics are best described by linear models

E Nozari, MA Bertolero, J Stiso, L Caciagli… - Nature biomedical …, 2024 - nature.com
It is typically assumed that large networks of neurons exhibit a large repertoire of nonlinear
behaviours. Here we challenge this assumption by leveraging mathematical models derived …

Inferring multi-scale neural mechanisms with brain network modelling

M Schirner, AR McIntosh, V Jirsa, G Deco, P Ritter - elife, 2018 - elifesciences.org
The neurophysiological processes underlying non-invasive brain activity measurements are
incompletely understood. Here, we developed a connectome-based brain network model …

Estimation and validation of individualized dynamic brain models with resting state fMRI

MF Singh, TS Braver, MW Cole, SN Ching - NeuroImage, 2020 - Elsevier
A key challenge for neuroscience is to develop generative, causal models of the human
nervous system in an individualized, data-driven manner. Previous initiatives have either …

It's about time: Linking dynamical systems with human neuroimaging to understand the brain

YJ John, KS Sawyer, K Srinivasan, EJ Müller… - Network …, 2022 - direct.mit.edu
Most human neuroscience research to date has focused on statistical approaches that
describe stationary patterns of localized neural activity or blood flow. While these patterns …

Interpreting models interpreting brain dynamics

MM Rahman, U Mahmood, N Lewis, H Gazula… - Scientific reports, 2022 - nature.com
Brain dynamics are highly complex and yet hold the key to understanding brain function and
dysfunction. The dynamics captured by resting-state functional magnetic resonance imaging …

Large-scale neural recordings call for new insights to link brain and behavior

AE Urai, B Doiron, AM Leifer, AK Churchland - Nature neuroscience, 2022 - nature.com
Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …

Neuronal cascades shape whole-brain functional dynamics at rest

G Rabuffo, J Fousek, C Bernard, V Jirsa - Eneuro, 2021 - eneuro.org
At rest, mammalian brains display remarkable spatiotemporal complexity, evolving through
recurrent functional connectivity (FC) states on a slow timescale of the order of tens of …

Quasiuniversal scaling in mouse-brain neuronal activity stems from edge-of-instability critical dynamics

GB Morales, S Di Santo… - Proceedings of the …, 2023 - National Acad Sciences
The brain is in a state of perpetual reverberant neural activity, even in the absence of
specific tasks or stimuli. Shedding light on the origin and functional significance of such a …

Resting-state fMRI dynamics and null models: perspectives, sampling variability, and simulations

RL Miller, A Abrol, T Adali, Y Levin-Schwarz… - Frontiers in …, 2018 - frontiersin.org
Studies of resting state functional MRI (rs-fRMI) are increasingly focused on “dynamics”, or
on those properties of brain activation that manifest and vary on timescales shorter than the …