Is the brain macroscopically linear? A system identification of resting state dynamics
A central challenge in the computational modeling of neural dynamics is the trade-off
between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are …
between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are …
Macroscopic resting-state brain dynamics are best described by linear models
It is typically assumed that large networks of neurons exhibit a large repertoire of nonlinear
behaviours. Here we challenge this assumption by leveraging mathematical models derived …
behaviours. Here we challenge this assumption by leveraging mathematical models derived …
Inferring multi-scale neural mechanisms with brain network modelling
The neurophysiological processes underlying non-invasive brain activity measurements are
incompletely understood. Here, we developed a connectome-based brain network model …
incompletely understood. Here, we developed a connectome-based brain network model …
Estimation and validation of individualized dynamic brain models with resting state fMRI
A key challenge for neuroscience is to develop generative, causal models of the human
nervous system in an individualized, data-driven manner. Previous initiatives have either …
nervous system in an individualized, data-driven manner. Previous initiatives have either …
It's about time: Linking dynamical systems with human neuroimaging to understand the brain
Most human neuroscience research to date has focused on statistical approaches that
describe stationary patterns of localized neural activity or blood flow. While these patterns …
describe stationary patterns of localized neural activity or blood flow. While these patterns …
Interpreting models interpreting brain dynamics
Brain dynamics are highly complex and yet hold the key to understanding brain function and
dysfunction. The dynamics captured by resting-state functional magnetic resonance imaging …
dysfunction. The dynamics captured by resting-state functional magnetic resonance imaging …
Large-scale neural recordings call for new insights to link brain and behavior
Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …
facing the challenge of connecting these brain-wide neural recordings to computation and …
Neuronal cascades shape whole-brain functional dynamics at rest
At rest, mammalian brains display remarkable spatiotemporal complexity, evolving through
recurrent functional connectivity (FC) states on a slow timescale of the order of tens of …
recurrent functional connectivity (FC) states on a slow timescale of the order of tens of …
Quasiuniversal scaling in mouse-brain neuronal activity stems from edge-of-instability critical dynamics
GB Morales, S Di Santo… - Proceedings of the …, 2023 - National Acad Sciences
The brain is in a state of perpetual reverberant neural activity, even in the absence of
specific tasks or stimuli. Shedding light on the origin and functional significance of such a …
specific tasks or stimuli. Shedding light on the origin and functional significance of such a …
Resting-state fMRI dynamics and null models: perspectives, sampling variability, and simulations
Studies of resting state functional MRI (rs-fRMI) are increasingly focused on “dynamics”, or
on those properties of brain activation that manifest and vary on timescales shorter than the …
on those properties of brain activation that manifest and vary on timescales shorter than the …