Background: Neutrophils and Lipocalin-2 (LCN2) play pivotal roles in cerebral
ischemiareperfusion (I/R) injury. However, their contribution is not fully clarified. Objective …

Background Functions of astrocytes in the rehabilitation after ischemic stroke, especially
their impacts on inflammatory processes, remain controversial. This study uncovered two …

Stroke is a leading cause of adult disability in the United States. However, limited number of
molecularly targeted therapy exists for stroke. Recent studies have shown that Li-pocalin-2 …

Stroke is the second leading cause of death worldwide; however, the treatment choices
available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted …

Oxidative stress is a key contributor to the pathogenesis of stroke-reperfusion injury.
Neuroinflammatory peptides released after ischemic stroke mediate reperfusion injury …

Thrombolysis remains the only effective therapy to reverse acute ischaemic stroke. However,
delayed treatment may cause serious complications including hemorrhagic transformation …

Stroke is a common and devastating disease with an escalating prevalence worldwide. The
known secondary injuries after stroke include cell death, neuroinflammation, blood-brain …

Ischemic and hemorrhagic stroke (including intracerebral hemorrhage, intraventricular
hemorrhage, and subarachnoid hemorrhage) is the dominating cause of disability and death …

Lipocalin-2 (LCN2) is a secreted protein of the lipocalin family, but little is known about the
expression or the role of LCN2 in the central nervous system. Here, we investigated the role …

Objectives From previous data in animal models of cerebral ischemia, lipocalin-2 (LCN2), a
protein related to neutrophil function and cellular iron homeostasis, is supposed to have a …