In the past decade, changes have occurred in the spectrum of multiple sclerosis courses.
The natural history of multiple sclerosis appears milder from the first sign of demyelinating …

The definition of multiple sclerosis (MS) is problematic. MS is best appreciated as a series of
syndromes with unique but overlapping clinical and pathological features. Each has a …

Multiple sclerosis can follow very different patterns of evolution and variable rates of
disability accumulation. This raises the issue whether it represents one or several distinct …

Classifications of multiple sclerosis subtypes have been largely based on clinical
phenomenology. Nevertheless, definitions of relapse, remission and progression have been …

Available therapies for multiple sclerosis patients, while effective during the relapsing phase,
have little benefit for progressive multiple sclerosis patients. Development of therapies to …

Detailed studies of the natural history of untreated multiple sclerosis (MS) have been carried
out in London, Ontario, Canada, over the past generation. There are now some 25,000 …

Natural history of multiple sclerosis: risk factors and prog... : Current Opinion in Neurology
Natural history of multiple sclerosis: risk factors and prognostic indicators : Current Opinion in …

The study's objectives were to assess the predictive significance of different sets of
demographic, clinical and extraclinical variables in identifying multiple sclerosis patients …

OBJECTIVES With increasing evidence that permanent tissue damage occurs early in the
course of multiple sclerosis, it is important that treatment trials include patients in the earliest …

BACKGROUND AND PURPOSE: Various authors have developed criteria to classify MR
imaging findings that suggest the possibility of multiple sclerosis. The purpose of this study …