Mouse models of Alzheimer's disease

G Esquerda-Canals, L Montoliu-Gaya… - Journal of …, 2017 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than
40 million people worldwide and it is predicted to exponentially increase in the coming …

A review of the current mammalian models of Alzheimer's disease and challenges that need to be overcome

NE Mckean, RR Handley, RG Snell - International journal of molecular …, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Modeling Alzheimer's disease with non-transgenic rat models

L Lecanu, V Papadopoulos - Alzheimer's research & therapy, 2013 - Springer
Abstract Alzheimer's disease (AD), for which there is no cure, is the most common form of
dementia in the elderly. Despite tremendous efforts by the scientific community, the AD drug …

Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

K Yamada, T Nabeshima - Pharmacology & therapeutics, 2000 - Elsevier
Alzheimer's disease (AD) is the most common cause of progressive decline of cognitive
function in aged humans, and is characterized by the presence of numerous senile plaques …

Transgenic mouse models of Alzheimer's disease

GA Elder, MA Gama Sosa… - Mount Sinai Journal of …, 2010 - Wiley Online Library
Alzheimer's disease is the most common cause of senile dementia in the United States and
Europe. At present, there is no effective treatment. Given the disease's prevalence and poor …

Modeling Alzheimer's disease in transgenic rats

S Do Carmo, AC Cuello - Molecular neurodegeneration, 2013 - Springer
Alzheimer's disease (AD) is the most common form of dementia. At the diagnostic stage, the
AD brain is characterized by the accumulation of extracellular amyloid plaques, intracellular …

Rodent models for Alzheimer's disease drug discovery

D Puzzo, W Gulisano, A Palmeri… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by
memory loss and personality changes, leading to dementia. Histopathological hallmarks are …

Animal models of Alzheimer disease

FM LaFerla, KN Green - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Significant insights into the function of genes associated with Alzheimer disease and related
dementias have occurred through studying genetically modified animals. Although none of …

Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions

M Kitazawa, R Medeiros… - Current pharmaceutical …, 2012 - ingentaconnect.com
Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no
effective treatment is available for AD. Analysis of transgenic mouse models of AD has …

Transgenic models of Alzheimer's disease: learning from animals

TL Spires, BT Hyman - NeuroRx, 2005 - Elsevier
As the scope of the problem of Alzheimer's disease (AD) grows due to an aging population,
research into the devastating condition has taken on added urgency. Rare inherited forms of …