The biological actions of estrogens are mediated by estrogen binding to one of two specific
estrogen receptors (ERs) ERα and ERβ, which belong to the nuclear receptor superfamily, a …

Human estrogen receptors α (ERα) and β (ERβ) are ligand-inducible transcription factors
that are highly homologous in their central DNA-binding and carboxyl-terminal ligand …

Estrogens act by binding to and activating two estrogen receptors (ERs), ERα and ERβ.
Transcriptional regulation by ERs is controlled by a complex array of factors such as ER …

Estrogen receptor beta (ER-β) regulates diverse physiological functions in the human body.
Current studies are confined to ER-β1, and the functional roles of isoforms 2, 4, and 5 …

The physiological effects of estrogens are mediated by two intracellular transcription factors,
the estrogen receptors (ERs), that regulate transcription of target genes through binding to …

Our understanding of estrogen signaling has undergone a true paradigm shift over recent
years, following the discovery in 1995 of a second estrogen receptor, estrogen receptor β …

The human estrogen receptor α (ERα) and the recently identified ERβ share a high degree
of amino acid homology; however, there are significant differences in regions of these …

The effects of estrogens, particularly 17β-estradiol (E2), are mediated by estrogen receptor α
(ERα) and ERβ. Upon binding to E2, ERs homo-and heterodimerize when coexpressed. The …

Together with the estrogen receptor (ER) alpha, estrogen receptor beta (ERβ) mediates
many of the physiological effects of estrogens. As ERβ is crucially involved in a variety of …

The discovery of a second estrogen receptor (ER), designated ERβ (NR3A2), has redefined
our knowledge about the mechanisms underlying cellular signaling by estrogens and has …