Atopic Dermatitis (AD), the most common chronic inflammatory skin disease, is
characterized by an overactive immune response to a host of environmental allergens and …

The pathology of atopic dermatitis is orchestrated on the cellular level by several different
cell types in the characteristic skin lesions. In such lesions, histamine as a mediator of many …

Atopic dermatitis (AD) and psoriasis are common skin diseases with a high negative impact
on patients' quality of life. Both diseases are mediated by a pro‐inflammatory infiltrate …

Along with antibiotics, antihistamines are the most widely used systemic drugs in
dermatology. This is attributable to the major role played by histamine in common diseases …

In this chapter we will first introduce the pathophysiological process of several skin diseases
including allergic dermatitis, a common skin disease, including chronic allergic contact …

Background Atopic dermatitis constitutes a most burdensome chronic inflammatory skin
disease. Standard treatment is cumbersome and often targets its main symptom, pruritus …

The diverse effects of histamine on immune regulation appear to be due to differential
expression and regulation of four types of histamine receptors and their distinct intracellular …

Histamine plays important roles in inflammation and nervous irritability in allergic disorders,
including atopic dermatitis (AD). It has been shown to regulate the expression of pruritic …

Although several lines of evidence support a role for histamine in the pathogenesis of atopic
dermatitis, antihistamines have generally offered only marginal therapeutic benefit. The …

BACKGROUND: Keratinocytes participate in initiation and amplification of T-cell–mediated
skin diseases. During these disorders, histamine can be released from both residents skin …