[HTML][HTML] Doença de Alzheimer: hipóteses etiológicas e perspectivas de tratamento

AD Falco, DS Cukierman, RA Hauser-Davis, NA Rey - Química Nova, 2016 - SciELO Brasil
With the increase in life expectancy registered in the past few decades, the prevalence of
various medical conditions related to aging has been observed, such as dementia and …

A doença de Alzheimer: aspectos fisiopatológicos e farmacológicos

A Sereniki, MABF Vital - Revista de psiquiatria do Rio Grande do Sul, 2008 - SciELO Brasil
A doença de Alzheimer é a patologia neurodegenerativa mais freqüente associada à idade,
cujas manifestações cognitivas e neuropsiquiátricas resultam em deficiência progressiva e …

[HTML][HTML] Early diagnosis and treatment of Alzheimer's disease: new definitions and challenges

M Pais, L Martinez, O Ribeiro, J Loureiro… - Brazilian Journal of …, 2020 - SciELO Brasil
The prevalence of Alzheimer's disease (AD), a progressive neurodegenerative disorder, is
expected to more than double by 2050. Studies on the pathophysiology of AD have been …

Current approaches against Alzheimer's disease in clinical trials

K Kuca, O Soukup, P Maresova, J Korabecny… - Journal of the Brazilian …, 2016 - SciELO Brasil
Alzheimer's disease (AD) is a progressive degenerative brain disease which causes mental
and physical decline, gradually resulting in death. Currently, this disease represents one of …

[HTML][HTML] Alzheimer's disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs

AR Monteiro, DJ Barbosa, F Remião, R Silva - Biochemical Pharmacology, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that
affect millions of people worldwide, with both prevalence and incidence increasing with age …

Treatment of Alzheimer's disease: beyond symptomatic therapies

FR Buccellato, M D'Anca, GM Tartaglia… - International Journal of …, 2023 - mdpi.com
In an ever-increasing aged world, Alzheimer's disease (AD) represents the first cause of
dementia and one of the first chronic diseases in elderly people. With 55 million people …

History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

[HTML][HTML] Overview of therapeutic targets in management of dementia

R Malik, S Kalra, S Bhatia, A Al Harrasi, G Singh… - Biomedicine & …, 2022 - Elsevier
Dementia is defined as a gradual cognitive impairment that interferes with everyday tasks,
and is a leading cause of dependency, disability, and mortality. According to the current …

Comprehensive review on Alzheimer's disease: causes and treatment

Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) is a disorder that causes degeneration of the cells in the brain and
it is the main cause of dementia, which is characterized by a decline in thinking and …

Alzheimer's disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

P dos Santos, C Leide, PF Ozela… - Current medicinal …, 2018 - ingentaconnect.com
Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …