Key points We investigated the excitation–contraction coupling mechanisms in small
pulmonary veins (SPVs) in rat precision‐cut lung slices. We found that SPVs contract …

Neither the electrophysiological effects of purinergic receptor stimulation nor the role of ATP
in regulating the tone of pulmonary arterial smooth muscle has been determined. Therefore …

BACKGROUND AND PURPOSE ATP, UTP and UDP act at smooth muscle P2X and P2Y
receptors to constrict rat intrapulmonary arteries, but the underlying signalling pathways are …

Abstract Background Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via
P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5' …

The effects of luminal ATP between rabbit pulmonary (PAs) and coronary arteries (CAs)
were compared to understand the role of purinoceptors in the regulation of pulmonary …

Changes in cytosolic free Ca2+ concentration ([Ca2+] i) induced by ATP and other P2
purinoceptor agonists were investigated using indo 1 microspectrofluorimetry in single …

Intrapulmonary veins (PVs) contribute to pulmonary vascular resistance, but the
mechanisms controlling PV tone are poorly understood. Although smooth muscle cell (SMC) …

We investigated cellular mechanisms that mediate or modulate the vascular response to
muscarinic receptor activation (ACh) in pulmonary veins (PV). Isometric tension was …

Uridine nucleotides are known to cause constriction of pulmonary arterial smooth muscle.
However, the P2 receptor subtypes underlying the contractile effects of these nucleotides in …

Pulmonary blood pressure is a function of the resistance of the intrapulmonary blood
vessels. Consequently, the mechanisms controlling blood vessel smooth muscle cell (SMC) …