Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein
which is highly expressed on a variety of pediatric solid embryonal tumors including the …

Purpose Glypican 3 (GPC3) is one of the cell surface heparan sulfate proteoglycans that
binds to the cell membrane, and it is known as an oncofetal protein in adult malignant …

Glypican-3 (GPC3), a 65 kD protein consisting of 580 amino acids, is a heparan sulfate
proteoglycan bound to the cell membrane by glycosylphosphatidylinositol. This protein is …

Hepatocellular carcinoma (HCC) remains a common malignant cancer worldwide. There is
an urgent need to identify new molecular targets for the development of novel therapeutic …

We developed an RNA-sequencing-based pipeline to discover differentially expressed cell-
surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target …

Abstract Glypican-3 (GPC3) is a cell surface oncofetal proteoglycan that is anchored by
glycosylphosphatidylinositol. Whereas GPC3 is abundant in fetal liver, its expression is …

Background Pediatric brain tumors are the leading cause of cancer death in children with an
urgent need for innovative therapies. Glypican 2 (GPC2) is a cell surface oncoprotein …

Abstract Glypican 3 (GPC3), a heparan sulfate proteoglycan, plays a role in cell growth and
differentiation. Mutations of the GPC3 gene are responsible for Simpson-Golabi-Behmel …

Glypican-3 (GPC3) is an oncofetal glycoprotein attached to the cell membrane by a
glycophosphatidylinositol anchor. GPC3 is overexpressed in some kinds of tumors …

Pediatric cancers often mimic fetal tissues and express proteins normally silenced
postnatally that could serve as immune targets. We developed T cells expressing chimeric …