Role of cardiomyocyte‐derived Exosomal MicroRNA‐146a‐5p in macrophage polarization and activation

C Chen, S Cai, M Wu, R Wang, M Liu, G Cao… - Disease …, 2022 - Wiley Online Library
Myocardial infarction arises from an excessive or prolonged inflammatory response, leading
to ventricular remodeling or impaired cardiac function. Macrophages exhibit different …

Inflammation-associated microRNA changes in circulating exosomes of heart failure patients

F Beg, R Wang, Z Saeed, S Devaraj, K Masoor… - BMC research …, 2017 - Springer
Abstract Objective MiR-486 and miR-146a are cardiomyocyte-enriched microRNAs that
control cell survival and self-regulation of inflammation. These microRNAs are released into …

[HTML][HTML] Extracellular miR-146a-5p induces cardiac innate immune response and cardiomyocyte dysfunction

BK Shimada, Y Yang, J Zhu, S Wang, A Suen… - …, 2020 - journals.aai.org
Previous studies have demonstrated that transient myocardial ischemia leads to release of
cellular nucleic acids such as RNA. Extracellular RNA reportedly plays a pivotal role in …

Exosomes Derived From Hypertrophic Cardiomyocytes Induce Inflammation in Macrophages via miR-155 Mediated MAPK Pathway

H Yu, L Qin, Y Peng, W Bai, Z Wang - Frontiers in Immunology, 2021 - frontiersin.org
The inflammatory immune microenvironment plays an important role in the development of
cardiac hypertrophy. Exosomes have emerged as the potent modulators of inflammatory …

Macrophage-derived mir-155-containing exosomes suppress fibroblast proliferation and promote fibroblast inflammation during cardiac injury

C Wang, C Zhang, L Liu, A Xi, B Chen, Y Li, J Du - Molecular Therapy, 2017 - cell.com
Inflammation plays an important role in cardiac injuries. Here, we examined the role of
miRNA in regulating inflammation and cardiac injury during myocardial infarction. We …

RETRACTED: BMSCs-derived exosomal microRNA-150-5p attenuates myocardial infarction in mice

Z Wu, S Cheng, S Wang, W Li, J Liu - 2021 - Elsevier
As such, a series of miRNAs were shuttled via exosomes, including miR-21, miR-98-5p, miR-
25, miR-30e, miR-125b, miR-126, miR-4732-3p, miR-146a, miR-185, miR-150-5p, miR-210 …

Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE−/− …

Y Yao, W Sun, Q Sun, B Jing, S Liu, X Liu… - Frontiers in …, 2019 - frontiersin.org
Introduction: Coronary artery disease originates from the blockage of the inner walls of the
coronary arteries due to a plaque buildup. Accumulating studies have highlighted the role of …

[HTML][HTML] Cardioprotection of M2 macrophages-derived exosomal microRNA-24-3p/Tnfsf10 axis against myocardial injury after sepsis

XC Sun, Y Liu, J Wang, M Zhang, M Wang - Molecular immunology, 2022 - Elsevier
Objective Some reports have suggested the involvement of microRNA-24-3p (miR-24-3p) in
heart diseases. Here, the intention of this work was to unmask whether miR-24-3p from M2 …

Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice

R Yue, S Lu, Y Luo, J Zeng, H Liang, D Qin… - Cell death …, 2022 - nature.com
Recent evidence indicates that exosomes derived from mesenchymal stem cells (MSCs)
confer protective effects against myocardial ischemia/reperfusion (I/R) injury. Exosomes are …

[HTML][HTML] Serum exosomal microRNA-146a as a novel diagnostic biomarker for acute coronary syndrome

LJ Li, YJ Gu, LQ Wang, W Wan, HW Wang… - Journal of Thoracic …, 2021 - ncbi.nlm.nih.gov
Background Circulating microRNAs (miRNAs) have emerged as potential biomarkers for
cardiovascular diseases. However, few studies have focused on the role of exosomal …