Vulnerability of the Hippocampus to Insults: Links to Blood–Brain Barrier Dysfunction

TL Davidson, RJ Stevenson - International Journal of Molecular Sciences, 2024 - mdpi.com
The hippocampus is a critical brain substrate for learning and memory; events that harm the
hippocampus can seriously impair mental and behavioral functioning. Hippocampal …

Sub-regional hippocampal vulnerability in various animal models leading to cognitive dysfunction

T Kadar, S Dachir, B Shukitt-Hale, A Levy - Journal of neural transmission, 1998 - Springer
Various animal models, involving different brain insults, lead to memory deficits, which can
be measured using behavioral tests. In numerous studies, using five different experimental …

[HTML][HTML] Single mild traumatic brain injury induces persistent disruption of the blood-brain barrier, neuroinflammation and cognitive decline in hypertensive rats

N Szarka, L Toth, A Czigler, Z Kellermayer… - International Journal of …, 2019 - mdpi.com
Traumatic brain injury (TBI) induces blood-brain barrier (BBB) disruption, which contributes
to secondary injury of brain tissue and development of chronic cognitive decline. However …

[HTML][HTML] Hippocampal activated microglia may contribute to blood–brain barrier impairment and cognitive dysfunction in post-traumatic stress disorder-like rats

K Ni, J Zhu, X Xu, Y Liu, S Yang, Y Huang, R Xu… - Journal of Molecular …, 2022 - Springer
Post-traumatic stress disorder (PTSD)-associated cognitive dysfunction significantly disturbs
patients' quality of life and will to live. However, its underlying mechanism is as yet unknown …

[HTML][HTML] Dangerous leaks: blood-brain barrier woes in the aging hippocampus

C Iadecola - Neuron, 2015 - cell.com
A leaky blood-brain barrier has long been implicated in cognitive dysfunction in aging and
neurodegeneration, but reliable human data were lacking. Here, Montagne et al.(2015) …

Selective neuronal vulnerability in the hippocampus: relationship to neurological diseases and mechanisms for differential sensitivity of neurons to stress

EK Michaelis - The clinical neurobiology of the hippocampus, 2012 - books.google.com
The phenomenon of selective neuronal vulnerability to neurological diseases or insults,
such as ischemia-reperfusion, brain trauma, and ageing-associated neurodegeneration …

[HTML][HTML] Effect of hypoproteic and high-fat diets on hippocampal blood-brain barrier permeability and oxidative stress

CC De Aquino, RA Leitão, LA Oliveira Alves… - Frontiers in …, 2019 - frontiersin.org
Worldwide, millions of people are exposed to dietary imbalance that impacts in health and
quality of life. In developing countries, like in Brazil, in poor settings, dietary habits …

The hippocampus in aging and disease: from plasticity to vulnerability

T Bartsch, P Wulff - Neuroscience, 2015 - Elsevier
The hippocampus has a pivotal role in learning and in the formation and consolidation of
memory and is critically involved in the regulation of emotion, fear, anxiety, and stress …

Spatial dynamics of vascular and biochemical injury in rat hippocampus following striatal injury and Aβ toxicity

Z Amtul, C Frías, J Randhawa, DJ Hill, EJ Arany - Molecular Neurobiology, 2019 - Springer
The hippocampus, a brain region vital for memory and learning, is sensitive to the damage
caused by ischemic/hypoxic stroke and is one of the main regions affected by Alzheimer's …

Stress and vulnerability to brain damage

C Conrad, RL Wright… - Encyclopedia of …, 2009 - asu.elsevierpure.com
The hippocampus is intimately sensitive to stress hormones and responds to stress through
changes in structure, neurochemistry, and excitability. Both acute and chronic stress can …