TBX1 functions as a tumor suppressor in thyroid cancer through inhibiting the activities of the PI3K/AKT and MAPK/ERK pathways

N Wang, Y Li, J Wei, J Pu, R Liu, Q Yang, H Guan… - Thyroid, 2019 - liebertpub.com
Background: TBX1 is a member of the T-box family of transcription factors characterized by a
conserved DNA binding domain termed T-box. TBX1 has been reported to be …

TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57KIP2 repression

X Li, X Ruan, P Zhang, Y Yu, M Gao, S Yuan, Z Zhao… - Oncogene, 2018 - nature.com
The T-box transcription factor TBX3 has been implicated in the patterning and differentiation
of a number of tissues during embryonic development, and is overexpressed in a variety of …

[HTML][HTML] Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells

WL Du, Q Fang, Y Chen, JW Teng… - Molecular …, 2017 - spandidos-publications.com
Abstract T‑Box (TBX)‑2 is a member of the T‑box gene family, which is aberrantly expressed
in numerous types of malignant tumors, and has previously been demonstrated to be …

[HTML][HTML] TBX2 over-expression promotes nasopharyngeal cancer cell proliferation and invasion

Y Lv, M Si, N Chen, Y Li, X Ma, H Yang, L Zhang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
TBX2 is a member of the T box transcription factor family. Its expression and potential
biological functions in nasopharyngeal cancer (NPC) cells are studied here. We showed that …

Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer

J Yu, X Ma, KF Cheung, X Li, L Tian, S Wang, CW Wu… - Oncogene, 2010 - nature.com
T-box transcription factor 5 (TBX5) is a member of a phylogenetically conserved family of
genes involved in the regulation of developmental processes. The function of TBX5 in …

Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells

J Arribas, E Giménez, R Marcos, A Velázquez - Apoptosis, 2015 - Springer
T-box genes regulate development processes, some of these genes having also a role in
cell proliferation and survival. TBX15 is a T-box transcription factor that, recently, has been …

Expression, function, and regulation of the embryonic transcription factor TBX1 in parathyroid tumors

C Verdelli, L Avagliano, V Guarnieri, F Cetani… - Laboratory …, 2017 - nature.com
Transcription factors active in embryonic parathyroid cells can be maintained in adult
parathyroids and be involved in tumorigenesis. TBX1, the candidate gene of 22q11. 2 …

NF-κB Mediates the Expression of TBX15 in Cancer Cells

J Arribas, T Cajuso, A Rodio, R Marcos, A Leonardi… - PloS one, 2016 - journals.plos.org
TBX15 is a T-box transcription factor essential for development, also proposed as a marker
in prostate cancer; and, recently, its antiapoptotic function indicates a role in carcinogenesis …

The T‐box transcription factor Tbx2: its role in development and possible implication in cancer

A Abrahams, MI Parker, S Prince - IUBMB life, 2010 - Wiley Online Library
Tbx2 is a member of the T‐box family of transcription factors that are crucial in embryonic
development. Recent studies suggest that T‐box factors may also play a role in controlling …

[PDF][PDF] Expression and clinical significance of tbx2 in pancreatic cancer

S Duo, T Tiao-Dong, Z Lei, W Wei, S Hong-Li… - Asian Pac J Cancer …, 2009 - Citeseer
TBX2 is one of the family of genes encoding developmental transcription factors,
characterized by a 200 amino acid DNA binding domain (T-box), found to be related to …