Hypoxia, that is, an inadequate oxygen supply, is linked to neurodegeneration and patients
with cardiovascular disease are prone to Alzheimer's disease (AD). 2‐Oxoglutarate and …

Oxygen sensing and homeostasis is indispensable for the maintenance of brain structural
and functional integrity. Under low-oxygen tension, the non-diseased brain has the ability to …

Abstract Heme oxygenase-1 (HO-1), a 32 kDa stress protein mediating the degradation of
heme to ferrous iron, carbon monoxide and biliverdin/bilirubin, has been implicated in the …

Significance: Oxygen (O2) sensing is the fundamental process through which organisms
respond to changes in O2 levels. Complex networks exist allowing the maintenance of O2 …

Ischemic stroke is a common disease with a high disability rate and mortality, which brings
heavy pressure on families and medical insurance. Nowadays, the golden treatments for …

For the maintenance of cellular homeostasis and energy metabolism, an uninterrupted
supply of oxygen (O 2) is routinely required in the brain. However, under the impaired level …

Heme oxygenase, the rate-limiting step in heme catabolism, appears to play an important
role in a number of neurodegenerative disorders, such as Alzheimer disease. Interestingly …

The mechanisms responsible for oxidative damage, pathological brain iron deposition and
mitochondrial insufficiency in Alzheimer disease (AD) remain enigmatic. Heme oxygenase-1 …

Recent studies have revealed that the members of an ancient family of nonheme Fe 2+/2-
oxoglutarate-dependent dioxygenases (2-OGDO) are involved in the functions associated …

We determined whether oxidative stress is an early event in the pathogenesis of sporadic
Alzheimer disease (AD), and correlated oxidative stress with neuropsychological functions …