Empowering muscle stem cells for the treatment of duchenne muscular dystrophy

RL Filippelli, NC Chang - Cells Tissues Organs, 2022 - karger.com
Duchenne muscular dystrophy (DMD) is a devastating and debilitating muscle degenerative
disease affecting 1 in every 3,500 male births worldwide. DMD is progressive and fatal; …

Cell therapy strategies on Duchenne muscular dystrophy: A systematic review of clinical applications

A Akat, E Karaöz - Stem Cell Reviews and Reports, 2024 - Springer
Abstract Duchenne Muscular Dystrophy (DMD) is an inherited genetic disorder
characterized by progressive degeneration of muscle tissue, leading to functional disability …

Muscle stem cells in development, regeneration, and disease

X Shi, DJ Garry - Genes & development, 2006 - genesdev.cshlp.org
Somatic stem cell populations participate in the development and regeneration of their host
tissues. Skeletal muscle is capable of complete regeneration due to stem cells that reside in …

Cell based therapy for Duchenne muscular dystrophy

A Farini, P Razini, S Erratico, Y Torrente… - Journal of cellular …, 2009 - Wiley Online Library
Mutations in the dystrophin gene cause an X‐linked genetic disorder: Duchenne muscular
dystrophy (DMD). Stem cell therapy is an attractive method to treat DMD because a small …

Perspectives of stem cell therapy in D uchenne muscular dystrophy

M Meregalli, A Farini, M Belicchi, D Parolini… - The FEBS …, 2013 - Wiley Online Library
Muscular dystrophies are heritable and heterogeneous neuromuscular disorders
characterized by the primary wasting of skeletal muscle, usually caused by mutations in the …

The role of stem cells in muscular dystrophies

M Meregalli, A Farini, F Colleoni… - Current gene …, 2012 - ingentaconnect.com
Muscular dystrophies are heterogeneous neuromuscular disorders of inherited origin,
including Duchenne muscular dystrophy (DMD). Cell-based therapies were used to promote …

[HTML][HTML] Targeting muscle stem cell intrinsic defects to treat Duchenne muscular dystrophy

NA Dumont, MA Rudnicki - NPJ Regenerative medicine, 2016 - nature.com
Duchenne muscular dystrophy (DMD) is a genetic disease characterised by skeletal muscle
degeneration and progressive muscle wasting, which is caused by loss-of-function …

[HTML][HTML] Therapeutic strategies for Duchenne muscular dystrophy: an update

C Sun, L Shen, Z Zhang, X Xie - Genes, 2020 - mdpi.com
Neuromuscular disorders encompass a heterogeneous group of conditions that impair the
function of muscles, motor neurons, peripheral nerves, and neuromuscular junctions. Being …

[HTML][HTML] Duchenne muscular dystrophy disease severity impacts skeletal muscle progenitor cells systemic delivery

KK Saleh, C Switzler, MR Hicks, L Gane… - Frontiers in …, 2023 - frontiersin.org
Duchenne muscular dystrophy (DMD) is caused by an out-of-frame mutation in the DMD
gene that results in the absence of a functional dystrophin protein, leading to a devastating …

Cell therapy in Duchenne muscular dystrophy treatment: clinical trials overview

A Bajek, D Porowinska, T Kloskowski… - Critical Reviews™ in …, 2015 - dl.begellhouse.com
Duchenne muscular dystrophy (DMD), the most common and most severe form of all
muscular dystrophies, leads to progressive muscle fiber necrosis, fibroblast proliferation …